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Kinase Selectivity Assay from Article 10.1021/jm0611004: "Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)."
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
MK-2 IC50 Value Determination from Article 10.1021/jm0611004: "Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)."
Assay data:31 Active, 31 Activity ≤ 1 µM, 31 Tested
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
Inhibition of MAPKAPK5 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of MK2 pretreated for 30 mins before substrate addition measured after 2 hrs by IMAP assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of human recombinant MK2 expressed in Escherichia coli BL21(DE3) after 60 mins
Assay data:2 Active, 2 Activity ≤ 1 µM, 4 Tested
Aqueous solubility of the compound
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of MK5
Inhibition of MK3
Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested
Inhibition of MK2
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