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Binding affinity to VHL (unknown origin) incubated for 60 mins by FP based binding assay
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to VHL E3 ligase (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 5 Tested
Fluorescence Polarization Assay (10% in DMSO) from US Patent US11512083: "Compounds and methods for the enhanced degradation of targeted proteins"
Assay data:61 Active, 14 Activity ≤ 1 µM, 86 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescence Polarization Assay (1% in DMSO) from US Patent US11512083: "Compounds and methods for the enhanced degradation of targeted proteins"
Assay data:90 Active, 40 Activity ≤ 1 µM, 136 Tested
Fluorescence Polarization Assay (0.25% in DMSO) from US Patent US11512083: "Compounds and methods for the enhanced degradation of targeted proteins"
Assay data:37 Active, 1 Activity ≤ 1 µM, 38 Tested
Binding affinity to VBC (unknown origin) using FAM-DEALA-Hyp-YIPD as substrate by fluorescence polarization assay
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues) (unknown origin) expressed in Escherichia coli assessed as displacement of HIF-1alpha by fluorescence polarization assay
Surface Plasmon Resonance Assay from US Patent US10730870: "Compounds and methods for the enhanced degradation of targeted proteins"
Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested
Fluorescence Polarization Assay (0.25% DMSO) from US Patent US10730870: "Compounds and methods for the enhanced degradation of targeted proteins"
Assay data:36 Active, 1 Activity ≤ 1 µM, 37 Tested
Fluorescence Polarization Assay (10% DMSO) from US Patent US10730870: "Compounds and methods for the enhanced degradation of targeted proteins"
Assay data:62 Active, 14 Activity ≤ 1 µM, 87 Tested
Fluorescence Polarization Assay (1% DMSO) from US Patent US10730870: "Compounds and methods for the enhanced degradation of targeted proteins"
Assay data:89 Active, 40 Activity ≤ 1 µM, 134 Tested
Inhibition of VHL (unknown origin) by fluorescence polarization assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 5 Tested
Binding affinity to His-TEV-tagged VHL (54 to 213 residues) (unknown origin)/Elongin B (1 to 118 residues)/Elongin C (1 to 96 residues) expressed in Escherichia coli BL21(DE3) by FP assay
Assay data:6 Active, 3 Activity ≤ 1 µM, 8 Tested
Binding affinity to VBC (unknown origin) at 50 uM at 20 degC by surface plasmon resonance assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Binding affinity to VBC (unknown origin) at 50 uM at 10 degC by surface plasmon resonance assay
Binding affinity to VHL (unknown origin)/elongin C (unknown origin)/elongin B (unknown origin) by isothermal titration calorimetry-based assay
Displacement of FAM-labeled HIF-1alpha peptide from VBC (unknown origin) by fluorescence polarization assay
Assay data:21 Active, 17 Activity ≤ 1 µM, 21 Tested
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled HIF1alpha peptide addition measured after 2 hrs by fluorescence polarization assay
Assay data:5 Active, 2 Activity ≤ 1 µM, 9 Tested
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry
Assay data:15 Active, 7 Activity ≤ 1 µM, 17 Tested
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
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