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Cytochrome P450 Family 2 Subfamily C Member 9 (CYP2C9) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2931 Active, 3 Activity ≤ 1 nM, 133 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of wild type recombinant human histone lysine methyltransferase GLP (951 to 1235 residues) expressed in Escherichia coli Rosetta BL21 DE3 PlysS assessed as zinc ions ejection from Cys4-Zn finger at 100 uM by FluoZin-3 based fluorescence assay
Assay data:20 Active, 20 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of wild type recombinant human histone lysine methyltransferase G9a (913 to 1193 residues) expressed in Escherichia coli Rosetta BL21 DE3 PlysS assessed as zinc ions ejection from Cys4-Zn finger at 100 uM by FluoZin-3 based fluorescence assay
qHTS assay to identify small molecule antagonists of the sonic hedgehog signaling (Shh) pathway
Assay data:1356 Active, 2 Activity ≤ 1 nM, 487 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
GENE-TOX mutagenicity studies
Assay data:1995 Active, 3214 Tested
SummaryCompounds, Active
CCRIS mutagenicity studies
Assay data:4929 Active, 8266 Tested
qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary
Assay data:1147 Active, 1 Activity ≤ 1 nM, 122 Activity ≤ 1 µM, 9305 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity
Assay data:580 Active, 617 Tested
NCI In Vivo Anticancer Drug Screen. Data for tumor model Colon Carcinoma 38 (subcutaneous) in B6D2F1 (BDF1) mice
Assay data:341 Active, 1251 Tested
NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intracerebral) in B6D2F1 (BDF1) mice
Assay data:19 Active, 134 Tested
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