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p53 small molecule agonists, cell-based qHTS assay: Summary
Assay data:212 Active, 41 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
p53 small molecule agonists, cell-based qHTS assay
Assay data:87 Active, 5 Activity ≤ 1 nM, 180 Activity ≤ 1 µM, 9667 Tested
Compound was evaluated for inhibition of human KDR in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:12 Active, 3 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 101 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity towards human SLC6A3 in an in vitro assay with cellular components measured by scintillation counting
Assay data:119 Active, 21 Activity ≤ 1 µM, 1213 Tested
Binding affinity towards human TBXA2R in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:14 Active, 2 Activity ≤ 1 µM, 1022 Tested
Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader
Assay data:70 Active, 31 Activity ≤ 1 µM, 1177 Tested
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:82 Active, 4 Activity ≤ 1 µM, 1215 Tested
Compound was evaluated for inhibition of human ABCB11 in an in vitro assay with cellular components measured by filtration, liquid scintillation counting
Assay data:43 Active, 3 Activity ≤ 1 µM, 508 Tested
Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists, luciferase reporter gene qHTS assay in human keratinocytes: Summary
Assay data:1038 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same Project
Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: luciferase reporter gene qHTS assay in human keratinocytes
Assay data:1099 Active, 1 Activity ≤ 1 nM, 143 Activity ≤ 1 µM, 9667 Tested
Primary firefly luciferase (FLuc) qHTS assay for identification of artifact compounds.
Assay data:75 Active, 14 Activity ≤ 1 µM, 5098 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
In-Vitro Kinase Inhibition Assay from US Patent US10464902: "Multi-tyrosine kinase inhibitors derivatives and methods of use"
Assay data:10 Active, 3 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Z′-LYTE Screening Assay from US Patent US9205078: "N-methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide for the treatment of chronic myelogenous leukemia"
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
ABL1 Kinase Mobility-Shift Assay from US Patent US9205078: "N-methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide for the treatment of chronic myelogenous leukemia"
Competition Binding Assays from Article 10.1021/acschembio.5b01063: "Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors."
Assay data:26 Active, 2 Activity ≤ 1 µM, 29 Tested
KinEASE-STK Assay from Article 10.1021/cb500908d: "Identification and further development of potent TBK1 inhibitors."
Assay data:75 Active, 1 Activity ≤ 1 nM, 46 Activity ≤ 1 µM, 83 Tested
PLK Kinase Assay from Article 10.1021/bi7008745: "Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity."
Assay data:21 Active, 1 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 21 Tested
Kinase Inhibition Assay from US Patent US9617222: "Alkynyl indazole derivative and use thereof"
Assay data:48 Active, 1 Activity ≤ 1 nM, 48 Activity ≤ 1 µM, 48 Tested
NCI human tumor cell line growth inhibition assay. Data for the T-47D Non-Small Cell Lung cell line, single concentration
Assay data:3353 Active, 74196 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
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