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p53 small molecule agonists, cell-based qHTS assay
Assay data:87 Active, 5 Activity ≤ 1 nM, 180 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
Binding affinity towards human SLC6A4 in an in vitro assay with cellular components measured by scintillation counting
Assay data:148 Active, 75 Activity ≤ 1 µM, 1194 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity towards human SLC6A2 in an in vitro assay with cellular components measured by scintillation counting
Assay data:123 Active, 40 Activity ≤ 1 µM, 1197 Tested
Binding affinity towards human SLC6A3 in an in vitro assay with cellular components measured by scintillation counting
Assay data:119 Active, 21 Activity ≤ 1 µM, 1213 Tested
Assay data:99 Active, 36 Activity ≤ 1 µM, 927 Tested
Assay data:128 Active, 38 Activity ≤ 1 µM, 927 Tested
Assay data:137 Active, 27 Activity ≤ 1 µM, 927 Tested
Binding affinity towards human PGR in an in vitro assay with cellular components measured by scintillation counting
Assay data:87 Active, 51 Activity ≤ 1 µM, 927 Tested
Binding affinity towards human NR3C1 in an in vitro cell free assay measured by filtration, radioactivity method
Assay data:83 Active, 2 Activity ≤ 1 nM, 58 Activity ≤ 1 µM, 1095 Tested
Antagonist activity at human NR13 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:13 Active, 3 Activity ≤ 1 µM, 36 Tested
Agonist activity at human NR1I2 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:41 Active, 11 Activity ≤ 1 µM, 580 Tested
Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader
Assay data:41 Active, 16 Activity ≤ 1 µM, 1178 Tested
Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measured by membrane filtration
Assay data:31 Active, 1 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 927 Tested
Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measured by fluorescence polarization method
Assay data:27 Active, 1 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 1032 Tested
Binding affinity towards human AR in an in vitro assay with cellular components measured by scintillation counting
Assay data:69 Active, 48 Activity ≤ 1 µM, 927 Tested
Binding affinity towards rat Ar in an in vitro cell free assay measured by fluorescence polarization method
Assay data:45 Active, 19 Activity ≤ 1 µM, 667 Tested
Inhibition of human liver AOX using phthalazine as substrate incubated for 2.5 mins by HPLC-MS analysis
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Anti-hyperplasia activity in human MCF7 cells xenografted in Sprague-Dawley rat assessed as appearance of tall columnar phenotype in epithelial cells at 0.1 mg/kg, po once daily for 3 days by hematoxylin and eosin staining based assay
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Invivo agonist activity at estrogen receptor in CRL:CD(SD) rat assessed as appearance of low cuboidal phenotype of epithelium at 0.1 mg/kg, po administered for 4 days and measured at 4 hr post last dose on day 4 by hematoxylin and eosin staining based assay relative to control
Assay data:2 Active, 2 Tested
Invivo agonist activity at estrogen receptor in CRL:CD(SD) rat assessed as increase in uterine wet weight to body weight ratio at 60 mg/kg, po administered for 4 days and measured at 4 hr post last dose on day 4 relative to control
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