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Displacement of [3H]5-chloro-N-((2S,3R)-5,5,5-trifluoro-1-hydroxy-3-methylpentan-2-yl)thiophene-2-sulfonamide from gamma secretase in human SH-SY5Y cells by competitive binding assay
Assay data:8 Active, 2 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of gamma secretase-mediated amyloid beta (1 to 40) production in human SH-SY5Y cells
Assay data:13 Active, 2 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 14 Tested
Inhibition of human gamma secretase-mediated total amyloid beta production expressed in HEK cells
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
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