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Inhibition of maize HD1-A
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of maize HD1-B
Inhibition of maize HD2
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of HDAC8 (unknown origin) using Fluor de lys as substrate by fluorescence based analysis
Assay data:12 Active, 9 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of HDAC6 (unknown origin) using Fluor de lys as substrate by fluorescence based analysis
Assay data:16 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 16 Tested
Inhibition of HDAC1 (unknown origin) using Fluor de lys as substrate by fluorescence based analysis
Assay data:12 Active, 2 Activity ≤ 1 µM, 13 Tested
Inhibition of SIRT6 deacetylation (unknown origin) using p53K382Ac peptide as substrate
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of SIRT6 deacetylation (unknown origin) using H3K9Ac peptide as substrate
Inhibition of human recombinant HDAC1 using fluorogenic substrate measured after 30 mins
Assay data:26 Active, 24 Activity ≤ 1 µM, 29 Tested
Inhibition of human recombinant HDAC6 using fluorogenic substrate measured after 30 mins
Assay data:28 Active, 27 Activity ≤ 1 µM, 29 Tested
Caliper Endpoint Assay for HDAC Enzymatic Activity from US Patent US20230322747: "OXADIAZOLE HDAC6 INHIBITORS AND USES THEREOF"
Assay data:3 Active, 1 Activity ≤ 1 µM, 91 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Nanosyn Biochemical HDAC6 Assay ( from US Patent US20230322747: "OXADIAZOLE HDAC6 INHIBITORS AND USES THEREOF"
Assay data:177 Active, 171 Activity ≤ 1 µM, 178 Tested
Enzymatic Assay from US Patent US11535598: "Histone deacetylases (HDACs) inhibitors"
Assay data:26 Active, 1 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Cytotoxicity against human PC-9 cells assessed as decrease in drug tolerant population at 50 nM supplemented with fresh medium containing compound every 3 days for 9 days in presence of erlotinib by Beckman Coulter counting method
SummaryCompounds, ActivePubMed Citation
Agonist activity at Vitamin D receptor (unknown origin) by fluorescence polarization assay
Inhibition of recombinant human N-terminal GST-fused/C-terminal His-tagged HDAC4 (627 to 1084 residues) expressed in baculovirus infected Sf9 insect cells using fluorogenic HDAC class 2a substrate measured after 30 mins by fluorimetry
Assay data:1 Active, 5 Tested
Inhibition of recombinant human full-length C-terminal Flag-His6-tagged HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using fluorogenic HDAC substrate measured after 30 mins by fluorimetry
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of C-terminal His-tagged human HDAC3 (1 to 428 residues)/N-terminal GST tagged human NCOR2 (395 to 489) expressed in baculovirus infected Sf9 insect cells using fluorogenic HDAC substrate measured after 30 mins by fluorimetry
Assay data:6 Active, 2 Activity ≤ 1 µM, 6 Tested
Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in Sf9 insect cells using fluorogenic HDAC substrate 3 measured after 30 mins by fluorimetry
Assay data:2 Active, 1 Activity ≤ 1 µM, 6 Tested
Inhibition of human full-length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cell using fluorogenic HDAC class 2a substrate measured after 30 mins by fluorimetry
Assay data:5 Active, 2 Activity ≤ 1 µM, 5 Tested
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