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Binding affinity towards human ADRB2 in an in vitro assay with cellular components measured by radioactivity method
Assay data:58 Active, 21 Activity ≤ 1 µM, 952 Tested
SummaryRelated BioAssays by Target
Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:14 Active, 10 Activity ≤ 1 µM, 635 Tested
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
Assay data:66 Active, 1 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 1195 Tested
Binding affinity towards human ADRA1A in an in vitro assay with cellular components (NIBR assay) measured by scintillation proximity assay
Assay data:150 Active, 65 Activity ≤ 1 µM, 699 Tested
Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader
Assay data:42 Active, 2 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 969 Tested
Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
Assay data:29 Active, 1 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 34 Tested
Substrate activity at human OCT2 overexpressed in HEK293 cells at 2.5 uM incubated for 2 mins by LC-MS/MS analysis
Assay data:6 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition Assay from Article : "Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor."
Assay data:5 Active, 2 Activity ≤ 1 µM, 8 Tested
beta2 Adrenergic Receptor Binding Assay from Article 10.1021/jm800613s: "Synthesis of bivalent beta2-adrenergic and adenosine A1 receptor ligands."
Assay data:5 Active, 3 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
Assay data:39 Active, 39 Activity ≤ 1 nM, 39 Activity ≤ 1 µM, 39 Tested
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
Assay data:39 Active, 2 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 39 Tested
Cytochrome P450 Family 2 Subfamily D Member 6 (CYP2D6) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2225 Active, 268 Activity ≤ 1 µM, 9667 Tested
Primary qHTS assay for inhibitors of Glutamate pyruvate transaminase 2 (GPT2)
Assay data:249 Active, 449 Activity ≤ 1 µM, 100803 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2147 Active, 1 Activity ≤ 1 nM, 377 Activity ≤ 1 µM, 5242 Tested
Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes assessed as intrinsic Kd by liquid scintillation counting
Assay data:9 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 11 Tested
Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes by liquid scintillation counting
Assay data:11 Active, 5 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
Agonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Agonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
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