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Binding affinity towards human HTR2A in an in vitro assay with cellular components measured by membrane filtration
Assay data:140 Active, 4 Activity ≤ 1 nM, 75 Activity ≤ 1 µM, 414 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity towards human HRH1 in an in vitro assay measured by filtration
Assay data:151 Active, 1 Activity ≤ 1 nM, 90 Activity ≤ 1 µM, 1239 Tested
NCATS Parallel Artificial Membrane Permeability Assay (PAMPA) - Blood-Brain Barrier (BBB) Permeability Screen
Assay data:267 Active, 438 Tested
SummaryCompounds, ActivePubMed Citation
Cytochrome P450 Family 2 Subfamily C Member 9 (CYP2C9) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2931 Active, 3 Activity ≤ 1 nM, 133 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Cytochrome P450 Family 2 Subfamily C Member 19 (CYP2C19) small molecule antagonists: luciferase reporter qHTS assay
Assay data:3508 Active, 4 Activity ≤ 1 nM, 319 Activity ≤ 1 µM, 9667 Tested
Cytochrome P450 Family 2 Subfamily D Member 6 (CYP2D6) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2225 Active, 268 Activity ≤ 1 µM, 9667 Tested
Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2039 Active, 244 Activity ≤ 1 µM, 5242 Tested
MELAS cybrid survival enhancement under low glucose conditions
Assay data:264 Active, 4937 Tested
Anticonvulsant activity in maximal electroshock induced seizure TO mouse model assessed as suppression of tonic hind limb extension at 10 mg/kg, ip pretreated for 30 to 45 mins followed by maximal electroshock induction
Assay data:4 Active, 4 Tested
Human Nav1.2 (Voltage-gated sodium channels)
Assay data:6 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Rat Nav1.2 (Voltage-gated sodium channels)
Assay data:14 Active, 14 Tested
Anticonvulsant activity in Swiss albino mouse assessed as protection against maximal electroshock-induced seizures at 300 mg/kg, ip after 4 hrs
Assay data:6 Active, 16 Tested
Anticonvulsant activity in Swiss albino mouse assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, ip after 4 hrs
Assay data:3 Active, 16 Tested
Anticonvulsant activity in Swiss albino mouse assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, ip after 4 hrs
Assay data:1 Active, 16 Tested
Anticonvulsant activity in Swiss albino mouse assessed as protection against maximal electroshock-induced seizures at 300 mg/kg, ip after 0.5 hrs
Assay data:8 Active, 15 Tested
Anticonvulsant activity in Swiss albino mouse assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, ip after 0.5 hrs
Anticonvulsant activity in Swiss albino mouse assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, ip after 0.5 hrs
Assay data:2 Active, 16 Tested
qHTS assay to identify small molecule antagonists of the sonic hedgehog signaling (Shh) pathway: Summary
Assay data:1156 Active, 2 Activity ≤ 1 nM, 322 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule agonists of the constitutive androstane receptor (CAR) signaling pathway: Summary
Assay data:1090 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
A CellTox Green Cytotoxicity Assay to monitor cytotoxicity in HepG2 cells - 8 hour
Assay data:390 Active, 34 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
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