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Binding affinity to Bacillus subtilis guaA riboswitch
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to Clostridium difficile [5'-32P]guaA riboswitch by polyacrylamide gel electrophoresis method
Assay data:17 Active, 6 Activity ≤ 1 µM, 42 Tested
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as protection of cell membrane integrity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by LDH release assay relative to untreated control
Assay data:6 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by LDH release assay relative to untreated control
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by MTT assay relative to untreated control
Binding affinity to guanine riboswitch in Bacillus subtilis
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Competitive inhibition of human erythrocyte purine nucleoside phosphorylase assessed as inhibition of guanosine phosphorylysis after 30 mins by Lineweaver-Burk plot analysis
Assay data:1 Active, 4 Tested
Binding affinity to calf recombinant PNP Phe159Trp mutant expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysis
Assay data:1 Active, 1 Tested
Binding affinity to calf recombinant PNP Phe200Trp mutant expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry
Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of bovine PNP using 7-methylguanosine as substrate by spectrophotometric based coupled assay
Assay data:9 Active, 3 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 9 Tested
Inhibition of Plasmodium falciparum HGXPRT at pH 8.5
Assay data:4 Active, 1 Activity ≤ 1 µM, 8 Tested
Inhibition of human HGPRT at pH 8.5
Assay data:4 Active, 8 Tested
Inhibition of Plasmodium falciparum HGXPRT at pH 7.4
Assay data:4 Active, 4 Activity ≤ 1 µM, 11 Tested
Inhibition of human HGPRT at pH 7.4
Assay data:4 Active, 10 Tested
Compound was tested for inhibition of purine nucleoside phosphorylase using human erythro lysate
Assay data:4 Active, 1 Activity ≤ 1 µM, 7 Tested
Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP)
Assay data:8 Active, 6 Activity ≤ 1 µM, 16 Tested
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