BioAssays, Active for PubChem Compound (Select 10389239) - PubChem BioAssay - NCBI

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Items: 18

Select item 17990721.

Kinase Selectivity Assay from Article 10.1021/jm0611004: "Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)."

Source:: BindingDB

Protein Targets:: MAP kinase-activated protein kinase 3; ...
Total:: 6

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1799072

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 17990712.

MK-2 IC50 Value Determination from Article 10.1021/jm0611004: "Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)."

Source:: BindingDB

Protein Targets:: MAP kinase-activated protein kinase 2; ...
Total:: 1

Assay data:31 Active, 31 Activity ≤ 1 µM, 31 Tested

AID:: 1799071

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 13457953.

Human mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK subfamily)

Source:: IUPHAR/BPS Guide to PHARMACOLOGY

Protein Target:: MAP kinase-activated protein kinase 3

Assay data:1 Active, 1 Tested

AID:: 1345795

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 13457534.

Human mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK subfamily)

Source:: IUPHAR/BPS Guide to PHARMACOLOGY

Protein Target:: MAP kinase-activated protein kinase 5 isoform 1

Assay data:3 Active, 3 Tested

AID:: 1345753

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 13457375.

Human mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK subfamily)

Source:: IUPHAR/BPS Guide to PHARMACOLOGY

Protein Target:: MAP kinase-activated protein kinase 2 isoform 1

Assay data:6 Active, 6 Tested

AID:: 1345737

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 9776086.

Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB

Source:: Shanghai Institute of Organic Chemistry

Protein Targets:: Chain 1, Chymotrypsinogen A; ...
Total:: 3277

Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested

AID:: 977608

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 7674687.

Inhibition of MAPKAPK5 (unknown origin)

Source:: ChEMBL

Protein Target:: MAP kinase-activated protein kinase 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 767468

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 5989808.

Inhibition of MK2 pretreated for 30 mins before substrate addition measured after 2 hrs by IMAP assay

Source:: ChEMBL

Protein Target:: MAP kinase-activated protein kinase 2

Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested

AID:: 598980

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4930409.

Navigating the Kinome

Source:: Abbott Labs

Assay data:1497 Active, 1497 Tested

AID:: 493040

Summary Compounds, Active PubMed Citation

Select item 39057610.

Inhibition of human recombinant MK2 expressed in Escherichia coli BL21(DE3) after 60 mins

Source:: ChEMBL

Protein Target:: MAP kinase-activated protein kinase 2

Assay data:2 Active, 2 Activity ≤ 1 µM, 4 Tested

AID:: 390576

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 28846711.

Aqueous solubility of the compound

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 288467

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 28846312.

Inhibition of ERK2

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:2 Active, 2 Tested

AID:: 288463

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 28846013.

Inhibition of MNK1

Source:: ChEMBL

Protein Target:: MAP kinase-interacting serine/threonine-protein kinase 1

Assay data:2 Active, 4 Tested

AID:: 288460

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 28845914.

Inhibition of MK5

Source:: ChEMBL

Protein Target:: MAP kinase-activated protein kinase 5

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 288459

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 28845815.

Inhibition of MK3

Source:: ChEMBL

Protein Target:: MAP kinase-activated protein kinase 3

Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested

AID:: 288458

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 28845716.

Inhibition of TNFalpha production in U937 cells

Source:: ChEMBL

Assay data:15 Active, 30 Tested

AID:: 288457

Summary Compounds, Active PubMed Citation

Select item 28845617.

Inhibition of MK2

Source:: ChEMBL

Protein Target:: MAP kinase-activated protein kinase 2

Assay data:31 Active, 31 Activity ≤ 1 µM, 31 Tested

AID:: 288456

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 181118.

Experimentally measured binding affinity data derived from PDB

Source:: Shanghai Institute of Organic Chemistry

Protein Targets:: Chain 1, Chymotrypsinogen A; ...
Total:: 3073

Assay data:3073 Active, 3073 Tested

AID:: 1811

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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Target

Proteins (5)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (18)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (10)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (12)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (17)
BioAssays extracted from the literature
Other (1)
BioAssays deposited by other experimentalists

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BioAssays, Active for PubChem Compound (Select 10389239) (18)
PubChem BioAssay
Taxonomy Links for Protein (Select 685508515) (1)
Taxonomy
txid573046[Organism] (178)
Protein
GEO Profiles Links for Nucleotide (Select 48146048) (148)
GEO Profiles
Homo sapiens DNA cross-link repair 1C (DCLRE1C), transcript variant g, mRNA
Homo sapiens DNA cross-link repair 1C (DCLRE1C), transcript variant g, mRNA
gi|1675178651|ref|NM_001289078.2|

Nucleotide

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