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Inhibition of renin activity in human plasma
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant renin
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Oral bioavailability in dog
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of human plasma renin
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of recombinant human renin
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
In Vitro Renin IC50 Determinations (Tandem GFP FRET Assay) from Article 10.1016/j.bmcl.2007.04.052: "Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors."
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 7 Tested
Inhibition of plasma renin (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Partition coefficient, log P of the compound at pH 7.4
Assay data:2 Tested
Assay data:5 Tested
Aqueous solubility of the compound at pH 6.6 buffer
Inhibition of human recombinant renin in buffer
Assay data:33 Active, 14 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 36 Tested
Inhibition of renin in plasma
Assay data:17 Active, 6 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 17 Tested
Inhibition of renin
Assay data:8 Active, 2 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 9 Tested
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