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Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
Assay data:523 Active, 206263 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Assay data:2 Activity ≤ 1 µM, 4309 Tested
SummaryCompounds, activity ≤ 1 µM
Alphascreen assay for small molecules abrogating mHTT-CaM Interaction
Assay data:6896 Active, 193105 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Cell-based high throughput primary assay to identify activators of GPR151
Assay data:6756 Active, 646675 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human CYP2D6 expressed in baculosomes at 1 uM using MOBFC as substrate preincubated for 20 mins followed by substrate and NADP+ addition and measured after 30 mins by fluorescence assay
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human CYP2E1 expressed in baculosomes at 1 uM using EOMCC as substrate preincubated for 20 mins followed by substrate and NADP+ addition and measured after 30 mins by fluorescence assay
Assay data:1 Active, 4 Tested
Inhibition of human CYP3A4 expressed in baculosomes at 1 uM using BOMCC as substrate preincubated for 20 mins followed by substrate and NADP+ addition and measured after 30 mins by fluorescence assay
Hepatotoxicity in human HepaRG cells assessed as necrotic cell death at 1000 uM measured over 12 hrs by LDH assay
SummaryPubMed Citation
Hepatotoxicity in human HepaRG cells assessed as necrotic cell death at 500 uM measured over 12 hrs by LDH assay
Assay data:4 Tested
Hepatotoxicity in human HepaRG cells assessed as GSH depletion at 1000 uM after 12 hrs by ThiolTracker Violet dye-based fluorescence assay
Hepatotoxicity in human HepaRG cells assessed as GSH depletion at 500 uM measured over 12 hrs by ThiolTracker Violet dye-based fluorescence assay
Hepatotoxicity in human HepaRG cells assessed as GSH depletion at 500 uM after 3 to 12 hrs by ThiolTracker Violet dye-based fluorescence assay
Luminescence cell-based high throughput primary assay to identify inhibitors of TEAD-YAP interaction.
Assay data:9273 Active, 641570 Tested
Toxoplasma gondii HTS in the absence of IFN-y
Assay data:614 Active, 6425 Tested
Toxoplasma gondii inhibition HTS in the presence of IFN-y
Assay data:2597 Active, 69085 Tested
HIV1_TAR : FRET assay measuring displacement of FAM and TAMRA-labeled Tat peptide from HIV-1 TAR RNA.
Assay data:618 Active, 103146 Tested
SummaryCompounds, Active
AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of microphthalmia-associated transcription factor (MITF)
Assay data:5861 Active, 646275 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibitors of CDC25B-CDK2/CyclinA interaction
Assay data:680 Active, 93851 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
AlphaScreen-based biochemical high throughput primary assay to identify activators of the E3 ligase (FBW7).
Assay data:853 Active, 645212 Tested
qHTS screening for TAG (triacylglycerol) accumulators in algae
Assay data:367 Active, 43715 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
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