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Kinase Inhibition Assay from Article 10.1021/jm9903949: "Tyrosine kinase inhibitors. 16. 6,5,6-tricyclic benzothieno[3, 2-d]pyrimidines and pyrimido[5,4-b-] and -[4,5-b]indoles as potent inhibitors of the epidermal growth factor receptor tyrosine kinase."
Assay data:49 Active, 8 Activity ≤ 1 nM, 47 Activity ≤ 1 µM, 55 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of c-Src tyrosine kinase at 50 uM
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Protein kinase C at 50 uM
Inhibition of Platelet-derived growth factor receptor at 50 uM
Assay data:7 Tested
SummaryPubMed Citation
Inhibition against Insulin receptor kinase at 50 uM
Assay data:8 Tested
Inhibition of Fibroblast growth factor receptor at 50 uM
Concentration needed to inhibit the phosphorylation of a 14-residue fragment of phospholipase C-gamma1 by Epidermal growth factor receptor (prepared from human A431 carcinoma cell vesicles by immunoaffinity chromatography)
Assay data:50 Active, 9 Activity ≤ 1 nM, 48 Activity ≤ 1 µM, 56 Tested
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