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HTS to identify compounds that affect the blood-brain barrier permeability in vitro
Assay data:419 Active, 1260 Tested
SummaryCompounds, Active
High-throughput screening primary assay to identify small molecule activators of human guanylyl cyclase B (GC-B) receptor activity
Assay data:399 Active, 370620 Tested
Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Assay data:281 Active, 189401 Tested
Antitumor activity against human HT-29 cells xenografted in BALB/c mouse assessed as tumor growth inhibition at 250 mg/kg, ip followed by LED irradiation with repeated compound irradiation for thrice upto 3 weeks relative to control
Assay data:1 Tested
SummaryPubMed Citation
Photodynamic cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 3 hrs followed by fresh medium replacement and subsequent red LED irradiation measured after 24 hrs by MTT assay relative to control
Photodynamic cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 3 hrs followed by fresh medium replacement and subsequent blue LED irradiation measured after 24 hrs by MTT assay relative to control
Photodynamic cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 3 hrs followed by fresh medium replacement and subsequent white LED irradiation measured after 24 hrs by MTT assay relative to control
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
Assay data:186 Active, 9 Activity ≤ 1 µM, 11353 Tested
Various Assay from Article 10.1021/acs.jmedchem.1c00409: "Perspectives on SARS-CoV-2 Main Protease Inhibitors."
Assay data:473 Active, 1 Activity ≤ 1 nM, 248 Activity ≤ 1 µM, 795 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Fluorescence Titration Assay from Article 10.1074/jbc.M112.442335: "The chlorite dismutase (HemQ) from Staphylococcus aureus has a redox-sensitive heme and is associated with the small colony variant phenotype."
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
Tryptophan Fluorescence Assay from Article 10.1021/acs.biochem.6b01019: "Tryptophan-Rich Sensory Protein/Translocator Protein (TSPO) from Cyanobacterium Fremyella diplosiphon Binds a Broad Range of Functionally Relevant Tetrapyrroles."
Assay data:4 Active, 5 Tested
SummaryCompounds, ActivePubMed Citation
qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay validation screen against the NCATS LOPAC Collection
Assay data:10 Active, 7 Activity ≤ 1 µM, 1248 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
NCI human tumor cell line growth inhibition assay. Data for the KM12 Non-Small Cell Lung cell line, single concentration
Assay data:3444 Active, 76734 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Non-Small Cell Lung cell line, single concentration
Assay data:3073 Active, 74254 Tested
NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Non-Small Cell Lung cell line, single concentration
Assay data:5131 Active, 77082 Tested
NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell Lung cell line, single concentration
Assay data:4318 Active, 77515 Tested
NCI human tumor cell line growth inhibition assay. Data for the SW-620 Non-Small Cell Lung cell line, single concentration
Assay data:3653 Active, 76840 Tested
NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Non-Small Cell Lung cell line, single concentration
Assay data:5608 Active, 76570 Tested
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Non-Small Cell Lung cell line, single concentration
Assay data:2768 Active, 73031 Tested
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