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Inhibition of MDR1 in mouse L5178Y cells expressing human MDR1 assessed as doxorubicin-induced antiproliferative activity by measuring combination index at 1.4:1 compound to doxorubicin ratio measured after 48 hrs by MTT assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MDR1-mediated efflux-pump activity in mouse L5178Y cells expressing human MDR1 assessed as fluorescence activity ratio at 20 uM preincubated for 10 mins followed by rhodamine-123 addition measured after 20 mins by flow cytometry
Assay data:29 Tested
Inhibition of MDR1-mediated efflux-pump activity in mouse L5178Y cells expressing human MDR1 assessed as fluorescence activity ratio at 2 uM preincubated for 10 mins followed by rhodamine-123 addition measured after 20 mins by flow cytometry
Assay data:30 Tested
Inhibition of MDR1-mediated efflux-pump activity in mouse L5178Y cells expressing human MDR1 assessed as mean fluorescence intensity at 20 uM preincubated for 10 mins followed by rhodamine-123 addition measured after 20 mins by flow cytometry (Rvb = 7.1 to 18.6 No_unit)
Inhibition of MDR1-mediated efflux-pump activity in mouse L5178Y cells expressing human MDR1 assessed as mean fluorescence intensity at 2 uM preincubated for 10 mins followed by rhodamine-123 addition measured after 20 mins by flow cytometry (Rvb = 7.1 to 18.6 No_unit)
Inhibition of MDR1-mediated efflux-pump activity in mouse L5178Y cells expressing human MDR1 assessed as side scattered light at 20 uM preincubated for 10 mins followed by rhodamine-123 addition measured after 20 mins by flow cytometry (Rvb = 194.6 to 286.4 No_unit)
Inhibition of MDR1-mediated efflux-pump activity in mouse L5178Y cells expressing human MDR1 assessed as side scattered light at 2 uM preincubated for 10 mins followed by rhodamine-123 addition measured after 20 mins by flow cytometry (Rvb = 194.6 to 286.4 No_unit)
Antiproliferative activity against mouse L5178Y cells measured after 72 hrs by MTT assay
Assay data:4 Active, 30 Tested
SummaryCompounds, ActivePubMed Citation
Antiproliferative activity against mouse L5178Y cells expressing human MDR1 measured after 72 hrs by MTT assay
SummaryPubMed Citation
Inhibition of MDR1-mediated efflux-pump activity in mouse L5178Y cells expressing human MDR1 assessed as forward scattered light at 2 uM preincubated for 10 mins followed by rhodamine-123 addition measured after 20 mins by flow cytometry (Rvb = 455.7 to 509.9 No_unit)
Inhibition of MDR1-mediated efflux-pump activity in mouse L5178Y cells expressing human MDR1 assessed as forward scattered light at 20 uM preincubated for 10 mins followed by rhodamine-123 addition measured after 20 mins by flow cytometry (Rvb = 455.7 to 509.9 No_unit)
Selectivity index, ratio of IC50 for human MCF7 cells to IC50 for chloroquine-resistant Plasmodium falciparum Dd2
Assay data:13 Tested
Selectivity index, ratio of IC50 for human MCF7 cells to IC50 for chloroquine-sensitive Plasmodium falciparum 3D7
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in erythrocytes after 48 hrs by SYBR Green 1-based fluorescence assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 48 hrs by SYBR Green 1-based fluorescence assay
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