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Cytotoxicity against human PC-9 cells assessed as decrease in drug tolerant population at 50 nM supplemented with fresh medium containing compound every 3 days for 9 days in presence of erlotinib by Beckman Coulter counting method
Assay data:1 Active, 1 Tested
Summary
Cytotoxicity against human PC-9 cells assessed as decrease in cell number at 50 nM supplemented with fresh medium containing compound every 3 days for 9 days by Beckman Coulter counting method
Assay data:1 Tested
Selectivity ratio, ratio of inhibition of HDAC in human HeLa nuclear extract assessed as residual activity to inhibition of human recombinant HDAC6 assessed as residual activity
Assay data:16 Tested
Inhibition of human recombinant HDAC6 assessed as residual activity at 2 uM relative to control
Assay data:6 Tested
SummaryRelated BioAssays by Target
Inhibition of HDAC in human HeLa nuclear extract assessed as residual activity at 20 uM relative to control
Acute toxicity in Spinal muscular atrophy mouse assessed as survival rate
Assay data:2 Tested
Toxicity in Spinal muscular atrophy mouse assessed as survival rate after 5 days
Toxicity in Spinal muscular atrophy mouse assessed as survival rate
Inhibition of maize HD1-A
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of maize HD1-B
Inhibition of maize HD2
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Selectivity index, ratio of IC50 for inhibition of HDAC8 (unknown origin) to IC50 for inhibition of HDAC6 (unknown origin)
Assay data:12 Tested
Selectivity index, ratio of IC50 for inhibition of HDAC1 (unknown origin) to IC50 for inhibition of HDAC6 (unknown origin)
Inhibition of HDAC8 (unknown origin) using Fluor de lys as substrate by fluorescence based analysis
Assay data:12 Active, 9 Activity ≤ 1 µM, 13 Tested
Inhibition of HDAC6 (unknown origin) using Fluor de lys as substrate by fluorescence based analysis
Assay data:16 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 16 Tested
Inhibition of HDAC1 (unknown origin) using Fluor de lys as substrate by fluorescence based analysis
Assay data:12 Active, 2 Activity ≤ 1 µM, 13 Tested
Inhibition of SIRT6 deacetylation (unknown origin) using p53K382Ac peptide as substrate
Inhibition of SIRT6 deacetylation (unknown origin) using H3K9Ac peptide as substrate
Selectivity index, ratio of IC50 for human recombinant HDAC1 to IC50 for human recombinant HDAC6
Assay data:29 Tested
Inhibition of human recombinant HDAC1 using fluorogenic substrate measured after 30 mins
Assay data:26 Active, 24 Activity ≤ 1 µM, 29 Tested
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