BioAssays for PubChem Compound (Select 4117381) - PubChem BioAssay - NCBI

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Items: 14

Select item 17964191.

Caspase Inhibition Assay from Article 10.1021/jm0100537: "Potent and selective nonpeptide inhibitors of caspases 3 and 7."

Source:: BindingDB

Protein Targets:: Caspase-1; ...
Total:: 8

Assay data:26 Active, 20 Activity ≤ 1 µM, 30 Tested

AID:: 1796419

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 12594232.

Primary cell-based high-throughput screening assay for identification of small molecule agonists of Aedes aegypti NPYLR7 [Small Molecule Inhibitors of Mosquito Biting Behavior]

Source:: Fisher Drug Discovery Resource Center

Assay data:412 Active, 270665 Tested

AID:: 1259423

Summary Compounds, Active PubMed Citation Related BioAssays by Depositor

Select item 12593993.

mouse cGAS chemiluminescence screen

Source:: Fisher Drug Discovery Resource Center

Protein Target:: Cyclic GMP-AMP synthase

Assay data:241 Active, 161421 Tested

AID:: 1259399

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Target

Select item 12593984.

human cGAS chemiluminescence screen

Source:: Fisher Drug Discovery Resource Center

Protein Target:: Cyclic GMP-AMP synthase

Assay data:234 Active, 287414 Tested

AID:: 1259398

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Target

Select item 4315155.

Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assay

Source:: ChEMBL

Protein Target:: Caspase-3

Assay data:18 Active, 14 Activity ≤ 1 µM, 18 Tested

AID:: 431515

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 497316.

Inhibitory activity against Caspase-9

Source:: ChEMBL

Protein Target:: Caspase-9

Assay data:6 Active, 2 Activity ≤ 1 µM, 8 Tested

AID:: 49731

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 497107.

Inhibitory activity against Caspase-8

Source:: ChEMBL

Protein Target:: Caspase-8

Assay data:8 Tested

AID:: 49710

Summary PubMed Citation Related BioAssays by Target

Select item 497008.

Inhibitory activity against Caspase-7

Source:: ChEMBL

Protein Target:: Caspase-7

Assay data:8 Active, 6 Activity ≤ 1 µM, 8 Tested

AID:: 49700

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 495509.

Inhibitory activity against Caspase-6

Source:: ChEMBL

Protein Target:: Caspase-6

Assay data:3 Active, 1 Activity ≤ 1 µM, 8 Tested

AID:: 49550

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4954410.

Inhibitory activity against caspase-4

Source:: ChEMBL

Protein Target:: Caspase-4

Assay data:2 Active, 8 Tested

AID:: 49544

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 4952311.

Inhibitory activity against caspase-3

Source:: ChEMBL

Protein Target:: Caspase-3

Assay data:7 Active, 6 Activity ≤ 1 µM, 8 Tested

AID:: 49523

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4951712.

Inhibition of recombinant human caspase-3

Source:: ChEMBL

Protein Target:: Caspase-3

Assay data:23 Active, 18 Activity ≤ 1 µM, 29 Tested

AID:: 49517

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4950813.

Inhibitory activity against caspase-2

Source:: ChEMBL

Protein Target:: Caspase-2

Assay data:3 Active, 8 Tested

AID:: 49508

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 4935714.

Inhibitory activity against caspase-1

Source:: ChEMBL

Protein Target:: Caspase-1

Assay data:1 Active, 8 Tested

AID:: 49357

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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Target

Proteins (2)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (13)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (7)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (11)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (3)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Depositor Category

Literature Extraction (11)
BioAssays extracted from the literature
Other (3)
BioAssays deposited by other experimentalists

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BioAssays for PubChem Compound (Select 4117381) (14)
PubChem BioAssay
beta-fibrinogen, partial [Tchagra senegalus]
beta-fibrinogen, partial [Tchagra senegalus]
gi|46810751|gb|AAT01690.1|

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