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In Vitro Src Kinase Inhibition Test from Article 10.1021/jm030317k: "Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src."
Assay data:26 Active, 26 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
EGFR assay from Article 10.1016/0968-0896(96)00107-1: "Tyrphostins IV--highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines."
Assay data:17 Active, 7 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Selectivity ratio of IC50 for recombinant His-tagged human KDR expressed in insect Sf21 cells to IC50 for human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system
Assay data:44 Tested
SummaryPubMed Citation
Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells preincubated for 15 mins followed by substrate addition measured after 20 mins by HTRF assay
Assay data:36 Active, 24 Activity ≤ 1 µM, 44 Tested
Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addition measured after 20 mins by HTRF assay
Assay data:43 Active, 2 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 44 Tested
ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5
Assay data:4197 Tested
Summary
A screen for compounds that modulate the activity of the Staphylococcus aureus MgrA protein
Assay data:107 Active, 83548 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
A screen for compounds that inhibit the CapD enzyme of Bacillus anthracis
Assay data:320 Active, 139468 Tested
In vitro inhibitory concentration against src-tyrosine kinase
Assay data:28 Active, 28 Activity ≤ 1 µM, 28 Tested
Late stage results from the probe development effort to identify inhibitors of the Janus kinase 2 mutant JAK2V617F.
Assay data:158 Active, 38 Activity ≤ 1 µM, 188 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
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