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Homogeneous Enzyme Assay with SPA Beads from Article 10.1016/j.bmcl.2005.03.003: "Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase."
Assay data:43 Active, 43 Activity ≤ 1 µM, 45 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro
Assay data:13179 Tested
SummaryRelated BioAssays by Target
ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro
ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro
Biochemical screen of P. falciparum MAPK2
Assay data:13451 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Biochemical screen of P. falciparum CDPK4
Assay data:55 Active, 55 Activity ≤ 1 µM, 13451 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Biochemical screen of P. falciparum PK7
Assay data:2 Active, 2 Activity ≤ 1 µM, 13451 Tested
Biochemical screen of P. falciparum PK6
Assay data:65 Active, 65 Activity ≤ 1 µM, 13451 Tested
Biochemical screen of P. falciparum CDPK1
Assay data:181 Active, 181 Activity ≤ 1 µM, 13451 Tested
Inhibitory concentration against Streptococcus pneumoniae Phenylalanyl-tRNA synthetase
Assay data:3 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibitory concentration against Haemophilus influenzae Phenylalanyl-tRNA synthetase
Assay data:3 Active, 3 Activity ≤ 1 µM, 4 Tested
Inhibitory concentration against Staphylococcus aureus Phenylalanyl-tRNA synthetase
Assay data:43 Active, 43 Activity ≤ 1 µM, 50 Tested
Inhibition of P. falciparum 3D7
Assay data:13533 Active, 13533 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
XC50 for P. falciparum 3D7
Assay data:134 Activity ≤ 1 nM, 11161 Activity ≤ 1 µM, 13533 Tested
SummaryCompounds, activity ≤ 1 µM
Inhibition of P. falciparum LDH
Assay data:13533 Tested
Inhibition of HepG2 cell line
Assay data:2010 Active, 13533 Tested
SummaryCompounds, Active
Inhibition of P. falciparum Dd2
Assay data:7957 Active, 13533 Tested
Inhibition Frequency Index
Summary
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