BioAssays for PubChem Compound (Select 185617) - PubChem BioAssay - NCBI

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Select item 18752741.

Inhibition of MMP1 in human U2OS cells at 5 umol/L by peptide microarray-based fluorescence assay

Source:: ChEMBL

Protein Target:: Interstitial collagenase

Assay data:6 Tested

AID:: 1875274

Summary PubMed Citation Related BioAssays by Target

Select item 18752732.

Inhibition of MMP2 in human U2OS cells at 5 umol/L by peptide microarray-based fluorescence assay

Source:: ChEMBL

Protein Target:: 72 kDa type IV collagenase

Assay data:4 Tested

AID:: 1875273

Summary PubMed Citation Related BioAssays by Target

Select item 18752713.

Inhibition of MMP7 in human U2OS cells at 5 umol/L by peptide microarray-based fluorescence assay

Source:: ChEMBL

Protein Target:: Matrilysin

Assay data:4 Tested

AID:: 1875271

Summary PubMed Citation Related BioAssays by Target

Select item 18752704.

Inhibition of MMP9 in human U2OS cells at 5 umol/L by peptide microarray-based fluorescence assay

Source:: ChEMBL

Protein Target:: Matrix metalloproteinase-9

Assay data:6 Tested

AID:: 1875270

Summary PubMed Citation Related BioAssays by Target

Select item 18752695.

Inhibition of MMP13 in human U2OS cells at 5 umol/L by peptide microarray-based fluorescence assay

Source:: ChEMBL

Protein Target:: Collagenase 3

Assay data:5 Tested

AID:: 1875269

Summary PubMed Citation Related BioAssays by Target

Select item 18452286.

NCATS Parallel Artificial Membrane Permeability Assay (PAMPA) - Blood-Brain Barrier (BBB) Permeability Screen

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:267 Active, 438 Tested

AID:: 1845228

Summary Compounds, Active PubMed Citation

Select item 17458557.

NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:48 Active, 86 Activity ≤ 1 µM, 637 Tested

AID:: 1745855

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor

Select item 17458548.

NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C. elegans viability qHTS

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:25 Active, 678 Tested

AID:: 1745854

Summary Compounds, Active PubMed Citation Related BioAssays by Depositor

Select item 14847219.

Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay

Source:: ChEMBL

Assay data:14 Tested

AID:: 1484721

Summary PubMed Citation

Select item 148472010.

Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay

Source:: ChEMBL

Assay data:5 Active, 1 Activity ≤ 1 µM, 14 Tested

AID:: 1484720

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 148471911.

Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay

Source:: ChEMBL

Assay data:8 Active, 4 Activity ≤ 1 µM, 14 Tested

AID:: 1484719

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 148471812.

Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay

Source:: ChEMBL

Assay data:8 Active, 14 Tested

AID:: 1484718

Summary Compounds, Active PubMed Citation

Select item 148471713.

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay

Source:: ChEMBL

Assay data:6 Active, 14 Tested

AID:: 1484717

Summary Compounds, Active PubMed Citation

Select item 142149614.

Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 72 hrs by MTT assay

Source:: ChEMBL

Assay data:13 Tested

AID:: 1421496

Summary PubMed Citation

Select item 142149515.

Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay

Source:: ChEMBL

Assay data:3 Active, 13 Tested

AID:: 1421495

Summary Compounds, Active PubMed Citation

Select item 142149416.

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay

Source:: ChEMBL

Assay data:3 Active, 13 Tested

AID:: 1421494

Summary Compounds, Active PubMed Citation

Select item 142149317.

Antiproliferative activity against human A549 cells after 72 hrs by MTT assay

Source:: ChEMBL

Assay data:1 Active, 13 Tested

AID:: 1421493

Summary Compounds, Active PubMed Citation

Select item 136825818.

Inhibition of PKM2 in human HeLa cells assessed as reduction in cellular glycolytic rate after 6 hrs

Source:: ChEMBL

Protein Target:: Pyruvate kinase PKM

Assay data:2 Tested

AID:: 1368258

Summary PubMed Citation Related BioAssays by Target

Select item 126508519.

N-octanol/0.15 M NaHCO3 partition coefficient, log P of the compound after 5 hrs by spectrophotometric analysis

Source:: ChEMBL

Assay data:10 Tested

AID:: 1265085

Summary PubMed Citation

Select item 126508420.

N-octanol/0.15 M NaCl partition coefficient, log P of the compound after 5 hrs by spectrophotometric analysis

Source:: ChEMBL

Assay data:10 Tested

AID:: 1265084

Summary PubMed Citation

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BioActivity

Chemical Probes (1)
BioAssays with compounds reported as validated chemical probes

Active Compounds (27)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (8)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (30)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Depositor Category

Literature Extraction (112)
BioAssays extracted from the literature
NIH MLP (3)
BioAssays deposited by the NIH Molecular Libraries Program

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BioAssays for PubChem Compound (Select 185617) (115)
PubChem BioAssay
HCAR1 hydroxycarboxylic acid receptor 1 [Homo sapiens]
HCAR1 hydroxycarboxylic acid receptor 1 [Homo sapiens]
Gene ID:27198

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