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High-throughput screening primary assay to identify small molecule activators of human guanylyl cyclase B (GC-B) receptor activity
Assay data:399 Active, 370620 Tested
SummaryCompounds, Active
Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Assay data:281 Active, 189401 Tested
Primary qHTS for Inhibitors of ATXN expression
Assay data:2593 Active, 3 Activity ≤ 1 nM, 2671 Activity ≤ 1 µM, 361713 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
High-throughput screening primary assay to identify small molecule activators of human GC-A enzyme activity
Assay data:519 Active, 370620 Tested
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2
Assay data:6069 Active, 5332 Activity ≤ 1 µM, 575118 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of NF-kappaB DNA binding activity in human MOLM13 cells by ELISA
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
Downregulation of NF-kappaB1A transcription in human MOLM13 cells at 20 uM after 6 hrs by qRT-PCR analysis
Assay data:3 Active, 3 Tested
Upregulation of HSPA1A in human MOLM13 cells at 20 uM after 6 hrs by qRT-PCR analysis
Upregulation of heme oxygenase 1 in human MOLM13 cells at 20 uM after 6 hrs by qRT-PCR analysis
Cytotoxicity against human peripheral blood mononuclear cells assessed as decrease in cell viability at 50 uM after 48 hrs by annexin V-FITC/7-AAD staining based flow cytometry relative to control
Assay data:1 Tested
SummaryPubMed Citation
Cytotoxicity against human bone marrow cells assessed as decrease in cell viability at 50 uM after 48 hrs by annexin V-FITC/7-AAD staining based flow cytometry relative to control
Cytotoxicity against human U937 cells assessed as decrease in cell viability after 48 hrs by trypan blue staining method
Assay data:1 Active, 3 Tested
Cytotoxicity against human TUR cells assessed as decrease in cell viability after 48 hrs by trypan blue staining method
Cytotoxicity against human THP1 cells assessed as decrease in cell viability after 48 hrs by trypan blue staining method
Assay data:3 Tested
Cytotoxicity against human MV4-11 cells assessed as decrease in cell viability after 48 hrs by trypan blue staining method
Cytotoxicity against human MOLM13 cells assessed as decrease in cell viability after 48 hrs by trypan blue staining method
Cytotoxicity against human KG1 cells assessed as decrease in cell viability after 48 hrs by trypan blue staining method
Cytotoxicity against human Kasumi-1 cells assessed as decrease in cell viability after 48 hrs by trypan blue staining method
Cytotoxicity against human HL60 cells assessed as decrease in cell viability after 48 hrs by trypan blue staining method
Cytotoxicity against human HCT15 cells by SRB assay
Assay data:7 Tested
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