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Antiinflammatory activity against C57BL/6 mouse assessed as decrease in Tri-ADP-induced serum KC levels at 50 mg/kg, iv measured after 122 mins by ELISA method
Assay data:1 Tested
SummaryPubMed Citation
Antiinflammatory activity against C57BL/6 mouse assessed as decrease in MDP-induced serum KC levels at 50 mg/kg, iv stimulated measured after 122 mins by ELISA method
Inhibition of human NOD2 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated RIP2 phoshorylation measured after 90 mins by western blot method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human NOD2 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated reduction in IkappaBalpha expression measured after 90 mins by western blot method
Inhibition of human NOD2 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated p38 phosphorylation measured after 90 mins by western blot method
Inhibition of human NOD2 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated JNK phoshorylation measured after 90 mins by western blot method
Inhibition of human NOD2 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated ERK phosphorylation measured after 90 mins by western blot method
Cytotoxicity against human HEK-Blue hNOD2 cells assessed as cell viability measured by SRB assay
Inhibition of human NOD1 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated RIP2 phoshorylation measured after 90 mins by western blot method
Cytotoxicity against human HEK-Blue hNOD1 cells assessed as cell viability measured by SRB assay
Inhibition of human NOD1 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated reduction in IkappaBalpha expression measured after 90 mins by western blot method
Inhibition of human NOD1 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated p38 phosphorylation measured after 90 mins by western blot method
Inhibition of human NOD1 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated JNK phoshorylation measured after 90 mins by western blot method
Inhibition of human NOD1 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated ERK phosphorylation measured after 90 mins by western blot method
Inhibition of human NOD2 in human THP-1 cells assessed as inhibition of MDP stimulated IL-6 m-RNA expression measured after 150 mins by Real time quantitative reverse transcriptase PCR method
Inhibition of human NOD1 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated IL-6 m-RNA expression measured after 150 mins by Real time quantitative reverse transcriptase PCR method
Antagonist activity at human NOD2 in HEK-Blue hNOD2 cells assessed as secreted alkaline phosphatase reporter activity preincubated for 3 hrs followed by stimulated with MDP for 20 hrs by Spectrophotometer method
Assay data:18 Active, 2 Activity ≤ 1 µM, 45 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human NOD1 in HEK-Blue hNOD1 cells assessed as secreted alkaline phosphatase reporter activity preincubated for 3 hrs followed by stimulated with lauroyl-gamma-D-Glu-mDAP for 20 hrs by spectrophotometer method
Assay data:18 Active, 1 Activity ≤ 1 µM, 45 Tested
Antagonist activity at human NOD2 in HEK-Blue hNOD2 cells assessed as reduction in secreted alkaline phosphatase reporter activity at 10 uM preincubated for 3 hrs followed by stimulated with MDP for 20 hrs by Spectrophotometer method
Assay data:45 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at human NOD1 in HEK-Blue hNOD1 cells assessed as reduction in secreted alkaline phosphatase reporter activity at 10 uM preincubated for 3 hrs followed by stimulated with lauroyl-gamma-D-Glu-mDAP for 20 hrs by spectrophotometer method
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