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Lipophilicity of the compound, high-throughput logP using octanol-coated immobilized artificial membranes at pH 7.4
Assay data:11 Tested
SummaryPubMed Citation
Inverse agonist activity at RORgammat in human whole blood assessed as reduction in Con A/IL-23-stimulated IL-17 secretion after 72 hrs by ELISA
Assay data:5 Active, 3 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inverse agonist activity at RORgammat in rat whole blood assessed as reduction in Con A/IL-23-stimulated IL-17 secretion after 72 hrs by ELISA
Assay data:6 Active, 5 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of RORgammat in rat CD4+ T-cells polarized with Th17 cytokine mix assessed as inhibition of IL-17 secretion
Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulated IL-17 secretion after 48 hrs by ELISA
Assay data:10 Active, 10 Activity ≤ 1 µM, 11 Tested
Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assay
Assay data:14 Active, 13 Activity ≤ 1 µM, 14 Tested
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