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Inhibition of ATPgammaS-BODIPY binding to Thermotoga maritima His-tagged HK853 expressed in Escherichia coli BL21(DE3)pLysS Rosetta preincubated for 30 mins prior to ATPgammaS-BODIPY addition measured after 1 hr by coomassie staining-based SDS-PAGE analysis
Assay data:1 Active, 43 Tested
SummaryCompounds, ActivePubMed Citation
Binding affinity to Bacillus subtilis guaA riboswitch
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to Clostridium difficile [5'-32P]guaA riboswitch by polyacrylamide gel electrophoresis method
Assay data:17 Active, 6 Activity ≤ 1 µM, 42 Tested
Toxicity in Balb/c mouse at 2 mM, ip measured after 0 to 14 days
Assay data:6 Tested
SummaryPubMed Citation
Inhibition of Shigella dysenteriae Shiga toxin-induced mortality in Balb/c mouse exposed to 5 x LD50 Shigella toxin assessed as increase in mouse survival at 2 mM, ip dosed 1 after toxin injection measured after 24 to 48 hrs
Assay data:4 Active, 6 Tested
Inhibition of Shigella dysenteriae Shiga toxin-induced mortality in Balb/c mouse exposed to 5 x LD50 Shigella toxin assessed as increase in mouse survival at 2 mM, ip dosed 1 hr before toxin injection measured after 24 to 48 hrs
Inhibition of Shigella dysenteriae Shiga toxin-induced mortality in Balb/c mouse exposed to 5 x LD50 Shigella toxin assessed as reduction in symptomatic effects of toxin at 2 mM, ip preincubated with Stx for 1 hr measured after 0 to 14 days
Selectivity index, ratio of CC50 for cytotoxicity against African green monkey Vero cells to IC50 for nhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by neutral red uptake assay
Assay data:4 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as protection of cell membrane integrity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by LDH release assay relative to untreated control
Assay data:6 Active, 6 Tested
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by LDH release assay relative to untreated control
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by MTT assay relative to untreated control
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by neutral red uptake assay relative to untreated control
SummaryPubMed CitationRelated BioAssays by Target
Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by neutral red uptake assay
Assay data:11 Active, 32 Tested
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit
Assay data:23 Tested
Inhibition of Shigella dysenteriae Shiga toxin-induced mortality in Balb/c mouse exposed to 5 x LD50 Shigella toxin assessed as increase in mouse survival at 2 mM, ip preincubated with Stx for 1 hr measured after 0 to 14 days
SSB-PriA antibiotic resistant target AlphaScreen
Assay data:2577 Active, 432182 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
GENE-TOX mutagenicity studies
Assay data:1995 Active, 3214 Tested
SummaryCompounds, Active
Binding affinity to guanine riboswitch in Bacillus subtilis
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Competitive inhibition of human erythrocyte purine nucleoside phosphorylase assessed as inhibition of guanosine phosphorylysis after 30 mins by Lineweaver-Burk plot analysis
Assay data:1 Active, 4 Tested
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