BioAssays for PubChem Compound (Select 12000646) - PubChem BioAssay - NCBI

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Select item 4543361.

Inhibition of TIE2 in human HCT116 cells by cellular phosphorylation assay

Source:: ChEMBL

Protein Target:: Angiopoietin-1 receptor

Assay data:5 Active, 3 Activity ≤ 1 µM, 12 Tested

AID:: 454336

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4543352.

Inhibition of VEGFR3 in human HCT116 cells by cellular phosphorylation assay

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 3

Assay data:3 Active, 3 Activity ≤ 1 µM, 12 Tested

AID:: 454335

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4543343.

Inhibition of PDGFRbeta in human HCT116 cells by cellular phosphorylation assay

Source:: ChEMBL

Protein Target:: Platelet-derived growth factor receptor beta

Assay data:2 Active, 1 Activity ≤ 1 µM, 12 Tested

AID:: 454334

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4543334.

Inhibition of EGFR in human HCT116 cells by cellular phosphorylation assay

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:1 Active, 12 Tested

AID:: 454333

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 4543325.

Inhibition of Aurora-B in human HCT116 cells by cellular proliferation assay

Source:: ChEMBL

Protein Target:: Aurora kinase B

Assay data:2 Active, 12 Tested

AID:: 454332

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 4543316.

Inhibition of VEGFR3 by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 3

Assay data:18 Active, 10 Activity ≤ 1 µM, 21 Tested

AID:: 454331

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4543307.

Inhibition of PDGFRbeta by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Platelet-derived growth factor receptor beta

Assay data:24 Active, 32 Tested

AID:: 454330

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 4543288.

Inhibition of TIE2 by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Angiopoietin-1 receptor

Assay data:31 Active, 25 Activity ≤ 1 µM, 36 Tested

AID:: 454328

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4543279.

Inhibition of VEGFR2 by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 2

Assay data:21 Active, 14 Activity ≤ 1 µM, 25 Tested

AID:: 454327

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 45432610.

Inhibition of wild type EGF-R by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:26 Active, 18 Activity ≤ 1 µM, 36 Tested

AID:: 454326

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 45432511.

Inhibition of Aurora-B by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Aurora kinase B

Assay data:33 Active, 27 Activity ≤ 1 µM, 36 Tested

AID:: 454325

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 45432412.

Inhibition of Aurora-A by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Aurora kinase A

Assay data:34 Active, 28 Activity ≤ 1 µM, 36 Tested

AID:: 454324

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 45432313.

Residual activity of ZAP70 at 10 uM by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase ZAP-70

Assay data:3 Tested

AID:: 454323

Summary PubMed Citation Related BioAssays by Target

Select item 45432214.

Residual activity of YES at 10 uM by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Yes

Assay data:3 Tested

AID:: 454322

Summary PubMed Citation Related BioAssays by Target

Select item 45432115.

Residual activity of WNK3 at 10 uM by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase WNK3

Assay data:3 Tested

AID:: 454321

Summary PubMed Citation Related BioAssays by Target

Select item 45432016.

Residual activity of WNK2 at 10 uM by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase WNK2

Assay data:3 Tested

AID:: 454320

Summary PubMed Citation Related BioAssays by Target

Select item 45431917.

Residual activity of WEE1 at 10 uM by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Wee1-like protein kinase

Assay data:3 Tested

AID:: 454319

Summary PubMed Citation Related BioAssays by Target

Select item 45431818.

Residual activity of VRK1 at 10 uM by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase VRK1

Assay data:3 Tested

AID:: 454318

Summary PubMed Citation Related BioAssays by Target

Select item 45431719.

Residual activity of VEGFR3 at 10 uM by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 3

Assay data:3 Tested

AID:: 454317

Summary PubMed Citation Related BioAssays by Target

Select item 45431620.

Residual activity of VEGFR2 at 10 uM by microplate scintillation counting

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 2

Assay data:3 Tested

AID:: 454316

Summary PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (12)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (9)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (12)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (768)
BioAssays extracted from the literature

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