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Displacement of [3H]dofetilide from human ERG expressed in HEK293 cell membranes incubated for 90 mins by beta-counting method
Assay data:3 Active, 11 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Dose normalized AUC (infinity) in Sprague-Dawley rat at 6 mg/kg, po
Assay data:11 Tested
SummaryPubMed Citation
Dose normalized Cmax inSprague-Dawley rat at 6 mg/kg, po
Half life in Sprague-Dawley rat at 2 mg/kg, iv
Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv
Clearance in Sprague-Dawley rat at 2 mg/kg, iv
Assay data:10 Tested
Oral bioavailability in Sprague-Dawley rat at 6 mg/kg
Assay data:15 Tested
Clearance in rat liver microsomes
Clearance in human liver microsomes
Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assay
Assay data:16 Active, 5 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assay
Assay data:20 Active, 12 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 20 Tested
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