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Inhibition of HNE-induced pulmonary hemorrhage when the compound was administered before 30 or 45 min at the dose of 50 mg/kg; orally active
Assay data:7 Active, 7 Tested
SummaryCompounds, ActivePubMed Citation
Tested for the ability to inhibit bovine thrombin at 0.5 mM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
In vivo inhibitory activity against HNE-induced pulmonary hemorrhage was determined in rats after oral administration of 50 mg/kg
Assay data:6 Tested
SummaryPubMed Citation
Tested for the ability to inhibit pepsin at 0.2 mM
In vivo inhibitory activity against HNE-induced pulmonary hemorrhage was determined in hamsters after oral administration of 25 mg/kg
Assay data:9 Tested
In vivo HNE inhibitory activity of lung hemorrhage in 6-8 hamsters
Ability to inhibit HNE-induced pulmonary hemorrhage, was examined in vivo in hamsters, after administering the compound orally 30 min prior to intratracheal instillation of 25 microg of HNE
Tested for the ability to inhibit rat kidney enkephalinase at 0.5 mM
In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 50 mg/kg
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.
Assay data:15 Active, 11 Activity ≤ 1 µM, 20 Tested
Binding affinity for purified Human neutrophil elastase was determined in vitro.
Assay data:7 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 10 Tested
Tested for the ability to inhibit bovine liver cathepsin B at 0.5 mM
Tested for the ability to inhibit human neutrophil cathepsin G at 0.5 mM
Half life determined from epimerization data at 37 degree C in human blood serum 3
Half life determined from epimerization data at 37 degree C in human blood serum 2
Half life determined from epimerization data at 37 degree C in human blood serum 1
Half life determined from epimerization data at 37 degree C in human blood plasma
Half life determined from epimerization data at 37 degree C in buffered saline
Half life determined from epimerization data at 37 degree C in Tween 20 (81 mM)
Half life determined from epimerization data at 37 degree C in BigCHAP (33 mM); Not observed
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