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SHP2 Biochemical Assay from US Patent US12037345: "Heterobicyclic compounds for inhibiting the activity of SHP2"
Assay data:196 Active, 196 Activity ≤ 1 µM, 196 Tested
SummaryRelated BioAssays by Target
KRAS Biochemical Assay-BODIPY-GDP Exchange TR-FRET from US Patent US20240228512: "ACYCLIC OXAZEPINE COMPOUNDS COMPRISING A 6-AZA MOIETY AND USES THEREOF"
Assay data:70 Active, 62 Activity ≤ 1 nM, 70 Activity ≤ 1 µM, 70 Tested
PARP2 FP Assay from US Patent US20240228486: "SULFONE- AND SULFOXIMINE-BASED SELECTIVE PARP1 INHIBITORS"
Assay data:7 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
HIV RT Filter Binding IC50 Assay from US Patent US20240226130: "4'-THIONUCLEOSIDE ANALOGUES AND THEIR PHARMACEUTICAL USE"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
BET BRD Assay from US Patent US20240226096: "TREATMENT OF MYELOPROLIFERATIVE DISEASES AND DISORDERS WITH INHIBITORS OF BET FAMILY BDII BROMODOMAIN"
Assay data:14 Active, 4 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested
Enzyme Activity Assay from US Patent US12030897: "Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof"
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
In Vitro BRD4 (BD2) Enzymatic Activity Assay from US Patent US12030880: "Iminosulfanone compound as bromodomain protein inhibitor and pharmaceutical composition and medical use thereof"
Assay data:21 Active, 15 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
In Vitro BRD4 (BD1) Enzymatic Activity Assay from US Patent US12030880: "Iminosulfanone compound as bromodomain protein inhibitor and pharmaceutical composition and medical use thereof"
Assay data:21 Active, 2 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
Fluorescence Polarization Assay from US Patent US12030867: "Hsp90β selective inhibitors"
Assay data:17 Active, 15 Activity ≤ 1 µM, 18 Tested
Fluorescence Polarization Assay from US Patent US20240218021: "CYCLIN INHIBITORS"
Assay data:676 Active, 672 Activity ≤ 1 µM, 677 Tested
ERα TR-FRET Test from US Patent US20240217988: "ESTROGEN RECEPTOR ANTAGONIST"
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
KRASG12D Nucleotide Exchange Assay from US Patent US20240217982: "KRAS INHIBITORS"
Assay data:39 Active, 36 Activity ≤ 1 µM, 41 Tested
Evaluation of A2a Receptor Binding Affinity from US Patent US20240217978: "COMPOUND AS ADENOSINE A2a RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITION COMPRISING SAME"
Assay data:395 Active, 50 Activity ≤ 1 nM, 388 Activity ≤ 1 µM, 396 Tested
BTK Kinase Assay from US Patent US20240217973: "IMIDAZOPYRIDINE COMPOUNDS AND USE THEREOF"
Assay data:12 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
Surface Plasmon Resonance (SPR) Biosensor Assay from US Patent US20240208970: "SUBSTITUTED HYDANTOIN COMPOUNDS, METHODS FOR PREPARATION THEREOF AND USE THEREOF IN THE TREATMENT AND/OR PREVENTION OF A CORONA VIRUS DISEASE"
Assay data:15 Active, 15 Activity ≤ 1 µM, 16 Tested
SARS-CoV-2 Mpro Protease Enzyme Assay from US Patent US20240208970: "SUBSTITUTED HYDANTOIN COMPOUNDS, METHODS FOR PREPARATION THEREOF AND USE THEREOF IN THE TREATMENT AND/OR PREVENTION OF A CORONA VIRUS DISEASE"
Assay data:76 Active, 51 Activity ≤ 1 µM, 79 Tested
KRAS(G12C) and SOS1 Binding Assay from US Patent US20240208945: "6-CARBAMATE SUBSTITUTED HETEROARYL RING DERIVATIVES"
Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested
SOS1/KRAS-G12D Binding Inhibition Assay from US Patent US20240208909: "SUBSTITUTED QUINOLINE DERIVATIVES HAVING SOS1 INHIBITION ACTIVITIES AND USES THEREOF"
Assay data:75 Active, 96 Activity ≤ 1 µM, 96 Tested
In Vitro Enzyme IC50 Assay from US Patent US20240207292: "BORONIC ACID COMPOUNDS, COMPOSITIONS AND METHODS"
Assay data:93 Active, 7 Activity ≤ 1 nM, 93 Activity ≤ 1 µM, 93 Tested
PTPN2 Biochemical Assay from US Patent US20240207238: "INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE"
Assay data:10 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
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