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Human Platelet Adhesion Assay from Article 10.1021/jm070252b: "Small molecule inhibitors of integrin alpha2beta1."
Assay data:25 Active, 25 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human alpha2 beta1 in human platelets assessed as reduction in platelet adhesion to collagen type 1 incubated for 30 mins
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human alpha2 beta1 expressed in CHO cells assessed as reduction in cell adhesion to collagen type 1 incubated for 5 mins by DiOC6 dye based fluorescence microscopy
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Antagonist activity at GP1a/GP2a receptor in human platelet rich plasma assessed as inhibition of platelet adhesion to fibrillar collagen at 10 to 100 uM preincubated with platelets for 30 mins followed by platelet adhesion to collagen measured after 1 hr in presence of Mg2+ by colorimetric method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at alpha2beta1 integrin receptor (unknown origin) by cell-free ELISA
Assay data:1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to alpha2beta1 integrin (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen type-1 after 3 hrs by solid phase ELISA-type assay
Assay data:31 Active, 33 Activity ≤ 1 µM, 44 Tested
Binding affinity to integrin alpha2 I-domain (unknown origin)
Assay data:2 Tested
Displacement of FITC-labeled fibrinogen from alpha2beta3 in human platelets
Assay data:9 Active, 8 Activity ≤ 1 µM, 10 Tested
Antagonist activity at integrin alpha2beta3-mediated aggregation in ADP-stimulated human platelets
Binding affinity to alpha2beta1 integrin expressed in CHO cells by flow cytometry
Inhibition of integrin alpha-2-beta-3-mediated aggregation in collagen-stimulated platelets at 30 uM
Inhibition of integrin alpha-2-beta-3-mediated aggregation in ADP-stimulated platelets at 30 uM
Inhibition of fibrinogen binding to alpha2beta3a integrin
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to integrin alpha2 expressed in human K562 cells at 1 uM for 30 mins by flow cytometry
Inhibition of integrin alpha-2-beta-1-mediated human K562 cells adhesion to collagen 1
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of integrin alpha-2-beta-1-mediated human platelets adhesion to collagen 1
Inhibition of integrin alpha-2 domain binding to collagen 1 by Europium-labeled anti-GST assay
Inhibition of integrin alpha-2 binding to collagen 4 at 50 uM
Inhibition of integrin alpha-2 domain binding to collagen 1 by Europium-labeled anti-GST assay relative to control
Assay data:4 Tested
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