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Inhibition of PNP (unknown origin) expressed in Escherichia coli
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant PNP
Assay data:6 Active, 3 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition Assay from US Patent US8853224: "Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases"
Assay data:31 Active, 6 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 31 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Competitive Inhibition Assay from Article 10.1021/bi00098a028: "Rational design of quinazoline-based irreversible inhibitors of human erythrocyte purine nucleoside phosphorylase."
Assay data:6 Tested
Inhibtion Assay from Article 10.1021/bi9005896: "Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase."
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
PNP Inhibition Assay from Article 10.1021/jm701265n: "Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases."
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Binding affinity to purine nucleoside phosphorylase (unknown origin)
Inhibition of human PNP
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human His-tagged PNP assessed as equilibrium dissociation constant by measuring reduction in uric acid formation by spectrophotometric method
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor complex formation by measuring reduction in uric acid formation by spectrophotometric method
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human PNP expressed in Escherichia coli assessed as reduction in uric acid formation by spectrophotometric method
Inhibition of human PNP assessed as inhibitor constant for enzyme-inhibitor-substrate complex formation
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of human PNP assessed as inhibitor constant for enzyme-inhibitor complex formation
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
Binding affinity to human PNP assessed as catalytic rate by measuring uric acid formation
Inhibition of recombinant human N-terminal His6-tagged PNP using inosine as substrate by xanthine oxidase coupled spectrophotometric method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of recombinant human PNP expressed in Escherichia coli BL21 (DE3) using inosine as substrate preincubated for 5.5 hrs followed by substrate addition by xanthine oxidase coupled assay
Inhibition of bovine spleen PNP assessed as dissociation half life using inosine as substrate by xanthine oxidase coupled assay
Inhibition of human PNP using inosine as substrate by xanthine oxidase coupled assay
Assay data:5 Active, 4 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of bovine spleen PNP using inosine as substrate by xanthine oxidase coupled assay
Assay data:3 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 4 Tested
Assay data:7 Active, 7 Activity ≤ 1 µM, 8 Tested
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