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Inhibition of Cytochrome P450 Oxidase from US Patent US20240158438: "POLYPEPTIDE COMPOUND AND APPLICATION THEREOF"
Assay data:2 Active, 31 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
CYP Enzyme Inhibition Assay from US Patent US11981669: "1,7-naphthyridine derivative and preparation method and use therefor"
Assay data:8 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
CYP Enzyme Inhibitory Activity IC50 Assay from US Patent US20240124479: "PYRIMIDINE CARBOXAMIDE COMPOUND AND USE THEREOF"
Assay data:1 Tested
Enzymatic Activity of CYP2C9, CYP2D6, and CYP3A4 from US Patent US20240124454: "TRICYCLIC COMPOUND AND USE THEREOF"
Assay data:10 Tested
CYP inhibitio from US Patent US20240124434: "ATF6 INHIBITORS AND USES THEREOF"
Assay data:10 Active, 3 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibitory Activity Assay from US Patent US11952364: "TRK inhibitors useful as anticancer drugs"
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis
Inhibition of CYP2C8 (unknown origin)
Inhibition of CYP2C9 (unknown origin)
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CYP2C19 (unknown origin)
Assay data:3 Tested
Assay data:1 Active, 1 Tested
Inhibition of CYP2C9 in human liver microsomes incubated for 10 mins in presence of NADPH by LC/MS/MS analysis
Assay data:2 Tested
Reversible inhibition of CYP2C19 in human liver microsomes assessed as residual activity at 5 uM using (S)-mephenytoin as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis relative to control
Reversible inhibition of CYP2C9 in human liver microsomes assessed as residual activity at 5 uM using diclofenac as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis relative to control
Assay data:4 Tested
Reversible inhibition of CYP2C8 in human liver microsomes assessed as residual activity at 5 uM using amodiaquine as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis relative to control
Inhibition of human CYP2C8
Assay data:1 Active, 2 Tested
Inhibition of human CYP2C9
Assay data:2 Active, 2 Tested
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