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Beta-Arrestin2 Recruitment Assay from US Patent US11912693: "Compounds for modulating S1P1 activity and methods of using the same"
Assay data:281 Active, 633 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Detecting Inhibition of cAMP Production from US Patent US11912693: "Compounds for modulating S1P1 activity and methods of using the same"
Assay data:260 Active, 633 Activity ≤ 1 µM, 633 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Biological Assay from US Patent US11701373: "Substituted bicyclic compounds"
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
GPCR beta-arrestin recruitment assay with target: S1PR1 Assay Type: PRESTO-Tango Concentration: 0.0000004
Assay data:211 Tested
SummaryRelated BioAssays by Target
GPCR beta-arrestin recruitment assay with target: S1PR1 Assay Type: PRESTO-Tango Concentration: 0.000002
GPCR beta-arrestin recruitment assay with target: S1PR1 Assay Type: PRESTO-Tango Concentration: 0.00001
Assay data:437 Tested
Agonist activity at S1P1 receptor (unknown origin) expressed in PathHunter HEK 293 EDG1 Total GPCR Internalization cells assessed as receptor internalization incubated for 90 mins by measuring chemiluminescence signal by microplate reader method
Assay data:43 Active, 2 Activity ≤ 1 nM, 65 Activity ≤ 1 µM, 65 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at S1P1 receptor (unknown origin) expressed in PathHunter CHO-K1 EDG1 beta-arrestin cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by measuring chemiluminescence signal by microplate reader method
Assay data:42 Active, 65 Activity ≤ 1 µM, 65 Tested
Binding affinity to recombinant human S1PR1 expressed in cell membrane
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of S1PR1 (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Binding affinity to S1PR1 (unknown origin) by SPR assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [32P]S1P from human recombinant S1PR1 incubated for 60 mins by competitive binding assay based scintillation counter
Assay data:1 Active, 8 Activity ≤ 1 µM, 8 Tested
Binding affinity to S1PR1 (unknown origin) assessed as dissociation constant by surface plasmon resonance analysis
Assay data:8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human S1P1 receptor expressed in CHO cells assessed as inhibition of calcium flux
Assay data:4 Tested
Homogenous Time-Resolved Fluorescence (HTRF) Assay for Direct cAMP Measurement from US Patent US11149292: "Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof"
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Receptor [35S] GTPgammaS Binding Assays from US Patent US11059784: "Oxime ether compounds"
Assay data:28 Active, 27 Activity ≤ 1 µM, 29 Tested
S1P1 Binding Assay from US Patent US11059784: "Oxime ether compounds"
Assay data:27 Active, 23 Activity ≤ 1 µM, 27 Tested
Receptor [35S] GTPgammaS Binding Assays: (S1P1 GTPgammaS/S1P3 GTPgammaS) from US Patent US11058696: "Substituted bicyclic compounds"
Assay data:12 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
S1P1 Binding Assay from US Patent US11058696: "Substituted bicyclic compounds"
S1P1 Binding Assay from US Patent US11046646: "Alkylphenyl compounds"
Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested
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