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Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate assessed as reduction in substrate hydroxylation incubated for 30 mins in presence of beta-NADPH measured by LC-MS/MS analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate assessed as reduction in substrate hydroxylation incubated for 5 mins in presence of beta-NADPH measured by LC-MS/MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Competitive inhibition of CYP2A6 (unknown origin)
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Mixed type inhibition of CYP2A6 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of CYP2A6 (unknown origin) assessed as residual activity preincubated for 10 mins
Assay data:8 Tested
Inhibition of CYP2A6 (unknown origin)
Assay data:8 Active, 6 Activity ≤ 1 µM, 8 Tested
Non competitive inhibition of CYP2A6 in human liver microsome using coumarin as substrate preincubated with NADPH for 5 mins and measured after 30 min by fluorescence spectroscopy
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Time dependent inhibition of CYP450 (unknown origin) at 10 uM
Inhibition of CYP450 (unknown origin) at 10 uM
Inhibition of CYP450 (unknown origin)
Induction of CYP450 in human assessed as reduction in tacrolimus AUC
Induction of CYP450 in human assessed as reduction in indinavir AUC
Induction of human CYP450 assessed as decrease in darunavir AUC
Assay data:2 Tested
Induction of CYP450 (unknown origin) assessed as decrease in 17alpha-ethinyl estradiol AUC
Induction of CYP450 in human assessed as reduction in amprenavir AUC
Induction of CYP450 in human assessed as reduction in nifedipine AUC
Induction of CYP450 in human assessed as reduction in midazolam AUC
Assay data:12 Tested
Induction of CYP450 in human assessed as reduction in Ivacaftor AUC
Induction of CYP450 in human assessed as reduction in rosiglitazone AUC at 600 mg, QD
Induction of CYP450 in human assessed as reduction in bupropion AUC at 200 mg, QD
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