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Binding affinity to Cathepsin S (unknown origin) assessed as inhibition constant measured after 22 hrs
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of cathepsin S activity in human PANC-1 cells at 6.25 to 25 uM incubated for 48 hrs by fluorescence-based assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of cathepsin S activity in human BXPC-3 cells at 6.25 to 25 uM incubated for 48 hrs by fluorescence-based assay
Inhibition of human cathepsin S
Assay data:5 Active, 25 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
D3R2028 from Article : "Drug Design Data Resource Grand Challenge 4 Dataset: CathepsinS"
Assay data:458 Active, 410 Activity ≤ 1 µM, 459 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
D3R2024 from Article : "Drug Design Data Resource Grand Challenge 3 Dataset: JAK2_SC3"
Assay data:11 Active, 6 Activity ≤ 1 µM, 17 Tested
D3R2020 from Article : "Drug Design Data Resource Grand Challenge 3 Dataset: CathepsinS"
Assay data:135 Active, 114 Activity ≤ 1 µM, 135 Tested
Inhibition of Cathepsin S (unknown origin) assessed as inhibition of AFC release using sequence VVR labelled with AFC as substrate by fluorescence based analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 5 Tested
Inhibition of human recombinant Cathepsin S using MCA-Arg-Pro-Lys-Pro-Val-Glu-NVAL-Trp-Arg-Lys-(DNP)-NH2 as substrate pretreated for 60 mins followed by substrate addition and incubated for 30 mins by microplate reader assay
Assay data:3 Tested
Inhibition of human recombinant Cathepsin S assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assay
Assay data:5 Tested
Inhibition of human cathepsin S at 1 uM incubated for 30 mins by fluorometric analysis
Assay data:7 Tested
Inhibition of human cathepsin S incubated for 30 mins by fluorometric analysis
Inhibition of human Cathepsin S assessed as inhibition constant
Assay data:1 Active, 1 Tested
Inhibition of Cathepsin S (unknown origin)
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of recombinant human cathepsin S using Z-VVR-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 10 mins by fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to S2 pocket of full-length human cathepsin S
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of human cathepsin S at 1 uM relative to control
Assay data:8 Tested
Inhibition of C-terminal His-tagged recombinant Human cathepsin S (17 to 331 residues) expressed in FreeStyle 293-F cells using Z-Leu-Arg-MCA peptide as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr by multimode plate reader analysis
Inhibition of human cathepsin S assessed as residual activity using Z-Phe-Val-Arg-pNA as substrate incubated for 60 mins by fluorometric assay
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