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Inhibition of gamma-secretase (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to his-tagged gamma-secretase (unknown origin) assessed as equilibrium constant by surface plasmon resonance analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Affinity Biochemical interaction (Radioligand binding assay for APP as target) EUB0000750a PSEN1
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Abeta42 inhibition assay (electrochemiluminescent detection of peptides secreted by SH-SY5Y cells stably overexpressing the APP C-terminal fragment SPA4CT)) EUB0000753a PSEN1
Affinity Phenotypic Cellular interaction (Abeta40 inhibition assay (in SH-SY5Y (SP4CT) cells; APP as target)) EUB0000750a PSEN1
Affinity Phenotypic Cellular interaction (Abeta40 inhibition assay (in SH-SY5Y (SP4CT) cells; APP as target)) EUB0000741a PSEN1
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Abeta42 inhibition assay (electrochemiluminescent detection of peptides secreted by SH-SY5Y cells stably overexpressing the APP C-terminal fragment SPA4CT)) EUB0000739a PSEN1
SummaryRelated BioAssays by Target
Inhibition of gamma secretase in human H4 cells expressing human wild type APP assessed as reduction in amyloid beta 1-42 level at 100 uM for 12 hrs by ELISA
Assay data:2 Tested
Inhibition of gamma secretase in human H4 cells expressing human wild type APP assessed as reduction in amyloid beta 1-40 level at 100 uM for 12 hrs by ELISA
Inhibition of gamma-secretase (unknown origin) assessed as inhibition of NICD cleavage
Inhibition of gamma secretase derived from human Hela cell membrane assessed as reduction in amyloid beta (1 to 40) production by ELISA
Inhibition of gamma-secretase (unknown origin) assessed as inhibition of Amyloid beta 42 production by cell-free assay
Inhibition of gamma-secretase (unknown origin) assessed as inhibition of Amyloid beta 40 production by cell-free assay
Inhibition of gamma-secretase (unknown origin) assessed as inhibition of Amyloid beta 40 production by cell-based assay
Inhibition of gamma-secretase in human H4 cells assessed as reduction in amyloid beta 42
Inhibition of gamma-secretase (unknown origin) assessed as decrease in Abeta42 levels
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Modulation of gamma-secretase (unknown origin) assessed as decrease in free Abeta42 levels
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Modulation of gamma-secretase (unknown origin) assessed as decrease in total Abeta42 levels
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as decrease in Abeta42 levels incubated for 2 hrs by sandwich ELISA
Assay data:4 Tested
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