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Inhibition of BLM in human HCT116 cells assessed as induction of telomere end loss at 4 uM by fluorescent in situ hybridization
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of BLM in human HCT116 cells assessed as upregulation of CHK2 phosphorylation by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of BLM in human HCT116 cells assessed as upregulation of CHK1 phosphorylation by Western blot analysis
Inhibition of BLM in human HCT116 cells assessed as upregulation of ATR phosphorylation up to 4 uM by Western blot analysis
Inhibition of BLM in human HCT116 cells assessed as upregulation of ATM phosphorylation up to 4 uM by Western blot analysis
Inhibition of BLM in human HCT116 cells assessed as potentiation of BIBR1532-induced cytotoxicity by measuring combination index at 1 to 2 uM measured after 48 hrs by MTT assay
Inhibition of BLM in human HCT116 cells assessed as increase in gamma-H2AX-TRF2 foci colocalization mediated telomere dysfunction-induced foci formation at 1 uM measured after 24 hrs in presence of PPAR inhibitor niraparib by DAPI staining based immunofluorescence assay
Inhibition of BLM in human HCT116 cells assessed as increase in gamma-H2AX-TRF2 foci colocalization mediated telomere dysfunction-induced foci formation at 1 to 4 uM measured after 24 hrs by DAPI staining based immunofluorescence assay relative to total gamma-H2AX foci
Inhibition of BLM in human HCT116 cells assessed as increase in gamma-H2AX-TRF2 foci colocalization mediated telomere dysfunction-induced foci formation measured after 24 hrs by DAPI staining based immunofluorescence assay
Inhibition of BLM in human HCT116 cells assessed as increase in gamma-H2AX foci at 1 to 4 uM measured after 24 hrs by DAPI staining based immunofluorescence assay
Inhibition of BLM in human HCT116 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring combination index at 1 to 2 uM measured after 48 hrs by MTT assay
Inhibition of BLM in human HCT116 cells assessed as potentiation of olaparib-induced cytotoxicity at 1 to 2 uM measured after 48 hrs by MTT assay
Inhibition of BLM in human HCT116 cells assessed as potentiation of niraparib-induced cytotoxicity at 1 to 2 uM measured after 48 hrs by MTT assay
Inhibition of BLM in human HCT116 cells assessed as potentiation of olaparib-induced cytotoxicity by measuring combination index at 1 to 2 uM measured after 48 hrs by MTT assay
Inhibition of BLM in human HCT116 cells assessed as potentiation of niraparib-induced cytotoxicity by measuring combination index at 1 to 2 uM measured after 48 hrs by MTT assay
Inhibition of BLM in human HCT116 cells assessed as potentiation of olaparib-induced cytotoxicity at 1 to 2 uM measured after 48 hrs by MTT assay relative to olaparib alone
Inhibition of BLM in human HCT116 cells assessed as potentiation of niraparib-induced cytotoxicity at 1 to 2 uM measured after 48 hrs by MTT assay relative to niraparib alone
Binding affinity to BLM in human HCT116 cells cotransfected with DSB model and I-SceI plasmid assessed as reduction in recruitment of protein to DNA region distant from DSB site at 2 uM measured after 24 hrs by chromatin immunoprecipitation assay
Binding affinity to BLM in human HCT116 cells cotransfected with DSB model and I-SceI plasmid assessed as reduction in recruitment of protein to DNA region distant from DSB site at 1 uM measured after 24 hrs by chromatin immunoprecipitation assay
Binding affinity to BLM in human HCT116 cells cotransfected with DSB model and I-SceI plasmid assessed as reduction in recruitment of protein to DSB site in DNA at 2 uM measured after 24 hrs by chromatin immunoprecipitation assay
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