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Inhibition of Shigella dysenteriae Alexa-488 labelled STXB retrograde transport from endosome to trans golgi network in human HeLa cells at 1 uM incubated with cells for 1 hr prior to STXB challenge incubated for 30 mins in ice followed by 45 mins incubation at 37 degC by phalloidin-Atto-550/DAPI staining based confocal microscopic analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to recombinant Shigella dysenteriae type 1 Shiga toxin A subunit assessed as fast off rate constant by SPR method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to recombinant Shigella dysenteriae type 1 Shiga toxin A subunit assessed as fast on rate constant by SPR method
Binding affinity to recombinant Shigella dysenteriae type 1 Shiga toxin A subunit by SPR method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by neutral red uptake assay
Assay data:4 Active, 9 Tested
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as protection of cell membrane integrity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by LDH release assay relative to untreated control
Assay data:6 Active, 6 Tested
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by LDH release assay relative to untreated control
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by MTT assay relative to untreated control
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by neutral red uptake assay relative to untreated control
Assay data:6 Tested
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-based thermal shift assay
Assay data:8 Active, 20 Tested
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit
Assay data:23 Tested
Concentration response confirmation assay for small molecule inhibitors of Shiga toxin
Assay data:4 Active, 1 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Concentration response cycloheximide confirmation counterscreen for small molecule inhibitors of Shiga toxin
Assay data:31 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
A qHTS for Small Molecule Inhibitors of Shiga Toxin (Summary)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
A qHTS for Small Molecule Inhibitors of Shiga Toxin (Confirmatory)
Assay data:100 Active, 14 Activity ≤ 1 nM, 125 Activity ≤ 1 µM, 506 Tested
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin (Confirmatory)
Assay data:17 Active, 6 Activity ≤ 1 µM, 506 Tested
A qHTS for Small Molecule Inhibitors of Shiga Toxin
Assay data:26913 Active, 293642 Tested
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin
Assay data:37055 Active, 296456 Tested
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