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Agonist activity at human CXCR3
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human wild type CXCR3
Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant CXCR3
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Antagonist activity at rat CXCR3
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Displacement of [125I]-CXCL10 from CXCR3 in human PBMC cells
Assay data:19 Active, 3 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 20 Tested
Induction of CXCR3 receptor internalization in mouse whole blood in presence of CXCl10 by flow cytometry
Antagonist activity at CXCR3 (unknown origin) by flow cytometry method
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Antagonist activity at CXCR3 (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Antagonist activity at CXCR3 (unknown origin) assessed as reduction in CXCL10 induced calcium flux by FLIPR method
Assay data:6 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 6 Tested
Antagonist activity at CXCR3 (unknown origin) assessed as reduction in CXCL11 induced calcium flux by FLIPR method
Assay data:8 Active, 7 Activity ≤ 1 µM, 9 Tested
Antagonist activity at CXCR3 (unknown origin) assessed as reduction in CXCL10 induced calcium flux by [35S]GTPgammaS binding assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Antagonist activity at CXCR3 (unknown origin) assessed as reduction in CXCL10 induced calcium flux by flow cytometry
Antagonist activity at CXCR3 (unknown origin) assessed as reduction in CXCL11 induced calcium flux by flow cytometry
Displacement of [125I]-CXCL10 from CXCR3 in human PBMC cells by scintillation proximity assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Antagonist activity at human CXCR3 assessed as reduction in CXCL11 induced calcium flux by [35S]GTPgammaS binding assay
Antagonist activity at mouse CXCR3 assessed as reduction in CXCL11 induced calcium flux by [35S]GTPgammaS binding assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
In vivo antagonist activity at CXCR3 in LPS-induced DBA/1 mouse model assessed as reduction in mouse CXCL10-mediated chemotaxis in CD8+ T cells at 0.06 microg/g, po bid preincubated for 3 days followed by LPS stimulation for 30 mins and measured after 3 days by flow cytometry
In vivo antagonist activity at CXCR3 in LPS-induced DBA/1 mouse model assessed as reduction in mouse CXCL10-mediated chemotaxis in CD8+ T cells at 0.02 microg/g, po bid preincubated for 3 days followed by LPS stimulation for 30 mins and measured after 3 days by flow cytometry
In vivo antagonist activity at CXCR3 in LPS-induced DBA/1 mouse model assessed as reduction in mouse CXCL10-mediated chemotaxis in CD8+ T cells at 0.006 microg/g, po bid preincubated for 3 days followed by LPS stimulation for 30 mins and measured after 3 days by flow cytometry
Binding affinity to CXCR3 (unknown origin) at 10 uM by radioligand binding assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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