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Mobility-Shift Assay from US Patent US11912663: "Multi-targeted tyrosine kinase inhibitors and their pharmaceutical uses"
Assay data:14 Active, 15 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
FLT1 SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of VEGFR1 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of FLT1 (unknown origin) at 1 uM relative to control
Inhibition of VEGFR1 (unknown origin) in presence of ATP
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant GST-fused VEGFR1 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mins in presence of gamma-[33P]-ATP by scintillation counting analysis
Assay data:9 Active, 8 Activity ≤ 1 µM, 9 Tested
Binding affinity to recombinant FLT1 (unknown origin) assessed as dissociation constant by DSF assay
Inhibition of recombinant FLT1 (unknown origin) at 10 uM by DSF assay relative to staurosporine
Binding affinity to recombinant FLT1 (unknown origin) assessed as change in melting temperature at 10 uM by DSF assay
Inhibition of VEGFR1 (unknown origin) at 1 uM using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA analysis relative to control
Inhibition of VEGFR1 (unknown origin) in the presence of ATP at Km concentration
Inhibition of VEGFR1 (unknown origin)
Inhibition of recombinant VEGFR1 (unknown origin) in the presence of [p33]-ATP
Inhibition of recombinant VEGFR1 (unknown origin) incubated for 60 mins by ELISA analysis
Enzyme-linked immunosorbent assay (ELISA) from US Patent US11655239: "Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof"
Assay data:32 Active, 18 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (Enzyme panel (CEREP screen)) EUB0000749a FLT1
Selectivity interaction (Kinase panel (activity or binding assay)) EUB0000674a FLT1
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