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Biological Assay from US Patent US20240182466: "A Crystal Form of a Fluorine-substituted Pyridopyrazole Compound and a Preparation Method Thereof"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
ITK Enzyme Assay from US Patent US20240124439: "Pyrido[2,3-D]Imidazole Derivatives and Their Use As Inhibitors of ITK for the Treatment of Skin Disease"
Assay data:119 Active, 116 Activity ≤ 1 µM, 119 Tested
ITK Enzyme Assay from US Patent US20240132477: "Benzimidazole Derivatives and Their Use As Inhibitors of ITK For The Treatment of Skin Disease"
Assay data:40 Active, 40 Activity ≤ 1 µM, 40 Tested
ITK Invitrogen Lab (UK) kinase screen (BI)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of ITK (unknown origin) at 1 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ITK (unknown origin) by Z'LYTE assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ITK (unknown origin) using Blk/Lyntide as substrate preincubated for 1 hr followed by substrate addition and measured after 2 hrs in presence of ATP by IMAP assay
Inhibition of ITK (unknown origin) by Ambit kinase assay
Inhibition of ITK (unknown origin)
Assay data:2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human ITK at 1 uM by hotspot assay relative to control
ITK Enzyme Assay from US Patent US20230280220: "Benzimidazole Derivative Compounds and Uses Thereof"
Assay data:54 Active, 2 Activity ≤ 1 nM, 54 Activity ≤ 1 µM, 54 Tested
ITK Enzyme Assay from US Patent US11661419: "Benzimidazole derivative compounds and uses thereof"
Selectivity interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a ITK
Selectivity interaction ( p-PLCg1 assay) EUB0000646a ITK
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Selectivity interaction (Z?-LYTE assay) EUB0000638a ITK
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