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Spectrophotometric Assay from US Patent US20240124427: "HYDROXYHETEROCYCLOALKANE-CARBAMOYL DERIVATIVES"
Assay data:115 Active, 115 Activity ≤ 1 µM, 115 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibitory Activity Assay from US Patent US20240109930: "TRIAZOLYL-METHYL SUBSTITUTED ALPHA-D-GALACTOPYRANOSIDE DERIVATIVES"
Assay data:245 Active, 244 Activity ≤ 1 µM, 245 Tested
Evaluation of Kd Values from US Patent US20240059728: "NOVEL GALACTOSIDE INHIBITOR OF GALECTINS"
Assay data:6 Active, 3 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Biological Assay from US Patent US20230348442: "GALECTIN-3 INHIBITING 2-HYDROXYCYCLOALKANE-1-CARBAMOYL DERIVATIVES"
Assay data:176 Active, 169 Activity ≤ 1 µM, 176 Tested
Evaluation of Compound Inhibitory Activity (IC50) from US Patent US20230295182: "SPIRO DERIVATIVES OF ALPHA-D-GALACTOPYRANOSIDES"
Assay data:115 Active, 112 Activity ≤ 1 µM, 115 Tested
Binding affinity to human galectin-3 by fluorescence polarization assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity against human US7 patient-derived BCP-ALL cells assessed as inhibition of galectin-3-mediated agglutination at 500 uM incubated for 2 hrs by phase contrast microscopy
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity against human TXL2 patient-derived BCP-ALL cells assessed as inhibition of galectin-3-mediated agglutination at 500 uM incubated for 2 hrs by phase contrast microscopy
Binding affinity to human galectin-3 using 2-(fluorescein-5/6-yl-carbonylamino)-ethyl 2-acetamido-2-deoxy-alpha-D-galactopyranosyl-(1-3)-[alpha-L-fucopyranosyl-(1-2)]-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranoside by fluorescence polarization analysis
Assay data:3 Active, 6 Tested
Inhibition of Alexa-Fluor-647 conjugated galectin-3 binding to human osteoarthritic cartilage at 4 mM of sugar preincubated for 1 hr followed by incubation with tissue material for overnight by 2-colour fluorescence microsocopy
Assay data:2 Active, 2 Tested
Inhibition of Alexa-Fluor-647 conjugated galectin-3 binding to C57BL/6 mouse medulla at 2 mM of sugar preincubated for 1 hr followed by incubation with tissue material for overnight by 2-colour fluorescence microsocopy
Inhibition of Alexa-Fluor-647 conjugated galectin-3 binding to C57BL/6 mouse kidney cortex at 2 mM of sugar preincubated for 1 hr followed by incubation with tissue material for overnight by 2-colour fluorescence microsocopy
Inhibition of biotinylated galectin-3 binding to C57BL/6 mouse kidney medulla at 125 to 500 uM of lactose residue per molecule preincubated for 1 hr followed by incubation with tissue material for overnight by light microsocopy
Assay data:3 Active, 3 Tested
Inhibition of biotinylated galectin-3 binding to C57BL/6 mouse kidney cortex at 125 to 500 uM of lactose residue per molecule preincubated for 1 hr followed by incubation with tissue material for overnight by light microsocopy
Inhibition of His-tagged recombinant mouse Gal-3 preincubated for 30 mins followed by B-ASF addition measured after 1 hr by time resolved fluorescence based assay
Assay data:21 Active, 11 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of His-tagged recombinant human Gal-3 preincubated for 30 mins followed by B-ASF addition measured after 1 hr by time resolved fluorescence based assay
Assay data:22 Active, 22 Activity ≤ 1 µM, 22 Tested
Binding affinity to mouse Galectin-3 assessed as dissociation constant
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Binding affinity to human galectin-3 assessed as dissociation constant by competitive fluorescence polarization assay
Assay data:9 Active, 7 Activity ≤ 1 µM, 11 Tested
Binding affinity to recombinant human Galectin-3 expressed in Escherichia coli assessed as dissociation constant by fluorescence polarization
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of human Gal3-induced chemotaxis using human monocyte incubated for 4 hrs by calcein-AM dye based assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
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