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Selectivity interaction (Methyltransferase panel (Scintillation proximity assay (SPA))) EUB0000212b NSD2
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Methyltransferase panel) EUB0000196bCl NSD2
Selectivity interaction (Epigenetic methyltransferases panel) EUB0000193b NSD2
Selectivity interaction (Protein methyltransferase panel (activity assay)) EUB0000211b NSD2
Inhibition of NSD2 (unknown origin) using histone H4 (1 to 21 residues) peptide/SAM as substrate incubated for 210 mins in presence of SAM by AlphaLISA assay
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to biotinylated human NSD2 PWWP1 domain (208 to 368 residues) expressed in Escherichia coli BL2I (DE3) cells assessed as dissociation constant by surface plasmon resonance analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human full length NSD2 at 10 uM by radioisotope-based filter binding assay
Protac activity at VHL E3 ligase/ NSD2 PWWP1 domain (208 to 369 residues) in human NCI-H929 cells assessed as induction of NSD2 degradation at 5 uM incubated for 72 hrs by Western blot analysis
Protac activity at VHL E3 ligase/ NSD2 PWWP1 domain (208 to 369 residues) in human KMS-11 cells assessed as induction of NSD2 degradation at 5 uM incubated for 72 hrs by Western blot analysis
Binding affinity to N-terminal GST-tagged human NSD2 PWWP1 domain (208 to 369 residues) expressed in Escherichia coli BL2I (DE3) cells at 25 uM by isothermal titration calorimetry assay
Binding affinity to N-terminal GST-tagged human NSD2 PWWP1 domain (208 to 369 residues) expressed in Escherichia coli BL2I (DE3) cells assessed as dissociation constant by isothermal titration calorimetry assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Protac activity at VHL E3 ligase/ NSD2 PWWP1 domain (208 to 369 residues) in HEK293FT cells assessed as induction of NSD2 degradation at 2.5 to 10 uM incubated for 48 hrs by Western blot analysis
Assay data:1 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Protac activity at VHL E3 ligase/ NSD2 PWWP1 domain (208 to 369 residues) in HEK293FT cells assessed as induction of NSD2 degradation at 0.1 to 0.5 uM incubated for 48 hrs by Western blot analysis
Inhibition of NSD2 (2 to 1365 residues) (unknown origin) at 1 uM expressed in baculovirus expression system using 3H-SAM as a substrate relative to control
Inhibition of NSD2 in human RS4-11 cells assessed as decrease in HSPG2 gene expression at 10 uM incubated for 72 hrs by RT-PCR analysis
Inhibition of NSD2 in human KMS-11 cells assessed as decrease in HSPG2 gene expression at 10 uM incubated for 72 hrs by RT-PCR analysis
Inhibition of NSD2 in human RS4-11 cells assessed as decrease in NCAM1 gene expression at 10 uM incubated for 72 hrs by RT-PCR analysis
Assay data:1 Active, 1 Tested
Inhibition of NSD2 in human KMS-11 cells assessed as decrease in NCAM1 gene expression at 10 uM incubated for 72 hrs by RT-PCR analysis
Inhibition of NSD2 in human RS4-11 cells assessed as decrease in TEMEL2 gene expression at 10 uM incubated for 72 hrs by RT-PCR analysis
Inhibition of NSD2 in human KMS-11 cells assessed as decrease in TEMEL2 gene expression at 10 uM incubated for 72 hrs by RT-PCR analysis
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