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Inhibition of TNKS1 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
Inhibition of human recombinant TNKS2 expressed in Escherichia coli assessed as inhibition at 20 uM measured after 48 hrs by fluorescence based analysis
Inhibition of human recombinant TNKS2
Inhibition of human recombinant TNKS1
Inhibition of human recombinant full length TNKS1 (1030 to 1317 residues) expressed in Escherichia coli assessed as inhibition by fluorescence based analysis
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of tankyrase-mediated auto-PARsylation in human DLD-1 cells assessed as increase in tankyrase accumulation incubated for 24 hrs
Assay data:1 Active, 1 Tested
Inhibition of TNKS2 (unknown origin)
Binding affinity to recombinant human TNKS1 (1091 to 1327 residues) assessed as dissociation constant by ITC method
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of TNKS2 (unknown origin) using biotinylated NAD as substrate assessed as inhibition of autoPARsylation activity incubated for 1 hr by ELISA
Assay data:22 Active, 4 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 23 Tested
Inhibition of TNKS1 (unknown origin) using biotinylated NAD as substrate assessed as inhibition of autoPARsylation activity incubated for 1 hr by ELISA
Assay data:23 Active, 4 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 24 Tested
Inhibition of TNKS1 (unknown origin) using biotinylated NAD as substrate assessed as inhibition of autoPARsylation activity incubated for 90 mins by TR-FRET analysis
Binding affinity to human TNKS2 ARC4 assessed as dissociation constant
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of TNKS2 (unknown origin) using biotin-NAD+ as substrate at 5 uM incubated for 1 hr by ELISA relative to control
Inhibition of TNKS1 (unknown origin) using biotin-NAD+ as substrate at 3 uM incubated for 1 hr by ELISA relative to control
Inhibition of human TNKS2 (873 to 1162 residues) measured after 15 hrs in presence of NAD+ by fluorescence assay
Assay data:8 Active, 2 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of human TNKS1 (1030 to 1317 residues) measured after 20 hrs
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
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