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Substrate activity at OCT1 (unknown origin) assessed as uptake ratio
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Substrate activity at human OCT1 overexpressed in HEK293 cells at 2.5 uM incubated for 2 mins by LC-MS/MS analysis
Assay data:6 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of OCT1 (unknown origin) overexpressed in HEK293 cells assessed as intracellular accumulation of ASP+ measured at 20 uM for 5 mins by Analyst AD plate reader method relative to control
Assay data:8 Tested
Inhibition of OCT1 (unknown origin) expressed in HEK293 cells
Assay data:1 Tested
Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake by measuring intrinsic clearance incubated for 2 mins by LC-MS/MS analysis
Assay data:22 Tested
Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake by measuring Vmax incubated for 2 mins by LC-MS/MS analysis
Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake by measuring Km incubated for 2 mins by LC-MS/MS analysis
Assay data:5 Active, 22 Tested
Inhibition of human OCT1 assessed as reduction in intracellular probe substrate accumulation upto 100 uM by microplate scintillation counter analysis relative to control
Inhibition of human OCT1 assessed as reduction in OCT1-mediated metformin transport at 14900 uM relative to control
Inhibition of OCT1 (unknown origin) expressed in HEK293 cells assessed as reduction of [ethyl 1-14C]TEA substrate uptake at 100 uM by liquid scintillation counting
Inhibition of OCT1 (unknown origin) expressed in HEK293 cells assessed as reduction of [14C]metformin substrate uptake at 100 uM by liquid scintillation counting
Drug uptake assessed as OCT1 (unknown origin)-mediated drug uptake expressed in HEK293 cells by liquid scintillation counting relative to control
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