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Time dependent inhibition of CYP450 (unknown origin) at 10 uM
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of CYP450 (unknown origin) at 10 uM
Inhibition of CYP450 (unknown origin)
Induction of CYP450 in human assessed as reduction in tacrolimus AUC
Induction of CYP450 in human assessed as reduction in indinavir AUC
Induction of human CYP450 assessed as decrease in darunavir AUC
Assay data:2 Tested
Induction of CYP450 (unknown origin) assessed as decrease in 17alpha-ethinyl estradiol AUC
Induction of CYP450 in human assessed as reduction in amprenavir AUC
Induction of CYP450 in human assessed as reduction in nifedipine AUC
Induction of CYP450 in human assessed as reduction in midazolam AUC
Assay data:12 Tested
Induction of CYP450 in human assessed as reduction in Ivacaftor AUC
Induction of CYP450 in human assessed as reduction in rosiglitazone AUC at 600 mg, QD
Induction of CYP450 in human assessed as reduction in bupropion AUC at 200 mg, QD
Inhibition of CYP450 in human liver microsomes
SummaryPubMed CitationRelated BioAssays by Target
Metabolic stability of the compound in human liver microsomes assessed as CYP450-mediated metabolism by measuring parent compound remaining at 0.5 uM measured after 10 mins in presence of NADPH by LC-MS/MS analysis
Metabolic stability in human liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining measured after 60 mins in presence of NADPH
Metabolic stability in human liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining measured after 30 mins in presence of NADPH
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