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KRAS Biochemical Assay-BODIPY-GDP Exchange TR-FRET from US Patent US20240228512: "ACYCLIC OXAZEPINE COMPOUNDS COMPRISING A 6-AZA MOIETY AND USES THEREOF"
Assay data:70 Active, 62 Activity ≤ 1 nM, 70 Activity ≤ 1 µM, 70 Tested
SummaryRelated BioAssays by Target
Determination of the Inhibitory Activity of the Compounds of the Present Invention on PARP1 Enzyme from US Patent US20240228490: "HETEROCYCLIC DERIVATIVE INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF"
Assay data:36 Active, 14 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 36 Tested
HIV RT Filter Binding IC50 Assay from US Patent US20240226130: "4'-THIONUCLEOSIDE ANALOGUES AND THEIR PHARMACEUTICAL USE"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Enzyme Activity Assay from US Patent US12030897: "Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof"
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
Fluorescence Polarization Assay from US Patent US12030867: "Hsp90β selective inhibitors"
Assay data:17 Active, 15 Activity ≤ 1 µM, 18 Tested
Fluorescence Polarization Assay from US Patent US20240218021: "CYCLIN INHIBITORS"
Assay data:676 Active, 672 Activity ≤ 1 µM, 677 Tested
ERα TR-FRET Test from US Patent US20240217988: "ESTROGEN RECEPTOR ANTAGONIST"
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
KRASG12D Nucleotide Exchange Assay from US Patent US20240217982: "KRAS INHIBITORS"
Assay data:39 Active, 36 Activity ≤ 1 µM, 41 Tested
BTK Kinase Assay from US Patent US20240217973: "IMIDAZOPYRIDINE COMPOUNDS AND USE THEREOF"
Assay data:12 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
LSD1 Enzyme Activity Assay from US Patent US20240216357: "POLYCYCLIC COMPOUND AND APPLICATION THEREOF"
Assay data:265 Active, 69 Activity ≤ 1 nM, 263 Activity ≤ 1 µM, 265 Tested
LSD1 Inhibition of the Crystal Form A of the Compound III from US Patent US12024494: "Salt of LSD1 inhibitor and a polymorph thereof"
Surface Plasmon Resonance (SPR) Biosensor Assay from US Patent US20240208970: "SUBSTITUTED HYDANTOIN COMPOUNDS, METHODS FOR PREPARATION THEREOF AND USE THEREOF IN THE TREATMENT AND/OR PREVENTION OF A CORONA VIRUS DISEASE"
Assay data:15 Active, 15 Activity ≤ 1 µM, 16 Tested
SARS-CoV-2 Mpro Protease Enzyme Assay from US Patent US20240208970: "SUBSTITUTED HYDANTOIN COMPOUNDS, METHODS FOR PREPARATION THEREOF AND USE THEREOF IN THE TREATMENT AND/OR PREVENTION OF A CORONA VIRUS DISEASE"
Assay data:76 Active, 51 Activity ≤ 1 µM, 79 Tested
KRAS(G12C) and SOS1 Binding Assay from US Patent US20240208945: "6-CARBAMATE SUBSTITUTED HETEROARYL RING DERIVATIVES"
Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested
SOS1/KRAS-G12D Binding Inhibition Assay from US Patent US20240208909: "SUBSTITUTED QUINOLINE DERIVATIVES HAVING SOS1 INHIBITION ACTIVITIES AND USES THEREOF"
Assay data:75 Active, 96 Activity ≤ 1 µM, 96 Tested
In Vitro Enzyme IC50 Assay from US Patent US20240207292: "BORONIC ACID COMPOUNDS, COMPOSITIONS AND METHODS"
Assay data:93 Active, 7 Activity ≤ 1 nM, 93 Activity ≤ 1 µM, 93 Tested
PI3K Biochemical Assay from US Patent US20240207263: "SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF"
Assay data:12 Tested
PTPN2 Biochemical Assay from US Patent US20240207238: "INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE"
Assay data:10 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
PhosphoSens Assay from US Patent US20240207238: "INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE"
Assay data:9 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 9 Tested
Inhibitory Activity against Enzyme hFXIa (Human Factor XIa) from US Patent US12018027: "Macrocyclic derivatives acting as XIa factor inhibitor"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
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