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Binding Assay from US Patent US10780092: "Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators"
Assay data:151 Active, 86 Activity ≤ 1 nM, 151 Activity ≤ 1 µM, 151 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
CHO Cellular Assay from US Patent US10550102: "Indane and indoline derivatives and the use thereof as soluble guanylate cyclase activators"
Assay data:159 Active, 92 Activity ≤ 1 nM, 159 Activity ≤ 1 µM, 159 Tested
Binding Assay from US Patent US10428076: "Soluble guanylate cyclase stimulators"
Assay data:231 Active, 214 Activity ≤ 1 nM, 231 Activity ≤ 1 µM, 231 Tested
Activation Assay from US Patent US9447090: "Imidazopyridine compounds"
Assay data:25 Active, 34 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Homogeneous Time Resolved Fluorescence Assay from US Patent US9353090: "Heterocyclic carboxylic acids as activators of soluble guanylate cyclase"
Assay data:323 Active, 6 Activity ≤ 1 nM, 323 Activity ≤ 1 µM, 323 Tested
Activation Assay from US Patent US9278968: "Imidazopyridine compounds"
Assay data:73 Active, 6 Activity ≤ 1 µM, 106 Tested
Stimulation of sGC Enzyme Activity from US Patent US10259776: "Branched 3-phenylpropionic acid derivatives and their use"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
HEK WC Assay from US Patent US10189809: "SGC stimulators"
Assay data:191 Tested
SummaryRelated BioAssays by Target
sGC-HEK-cGMP Assay from US Patent US10183021: "sGC stimulators"
Assay data:256 Active, 384 Activity ≤ 1 µM, 384 Tested
Stimulation of sGC Enzyme Activity from US Patent US10023528: "Branched 3-phenylpropionic acid derivatives and their use"
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
sGC Binding Assay from US Patent US10030027: "Soluble guanylate cyclase stimulators"
Assay data:233 Active, 216 Activity ≤ 1 nM, 233 Activity ≤ 1 µM, 233 Tested
GUACYCBASAL Cerep selectivity data (BI)
Assay data:1 Tested
Activation of full length human sGC alpha1/beta1 subunit containing heme in ferrous state expressed in Sf9 insect cells using cGMP as substrate incubated for 10 mins by [32P]GTP assay
Assay data:3 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of full length human sGC alpha1/beta1 subunit containing heme in ferric state expressed in Sf9 insect cells using cGMP as substrate incubated for 15 mins at 100 uM incubated for 10 mins by [32P]GTP assay relative to control
Assay data:7 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of full length human sGC alpha1/beta1 subunit containing heme in ferric state expressed in Sf9 insect cells using cGMP as substrate incubated for 15 mins by [32P]GTP assay
Assay data:27 Tested
Activation of human sGC assessed as increase in intracellular cGMP level in presence of DETA-NO and Tween-20
Activation of human sGC assessed as increase in intracellular cGMP level in presence of DETA-NO and ODQ
Activation of human sGC assessed as increase in intracellular cGMP level in presence of DETA-NO
Assay data:1 Active, 1 Tested
Activation of sGC (unknown origin) in presence of DETA-NO by Glosensor cGMP assay
Assay data:27 Active, 22 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of recombinant rat sGC alpha1 subunit expressed in CHO cells assessed as induction of [32P-cGMP] formation at 0.01 to 100 uM using alpha-[32P-GTP] as substrate measured after 6 mins in presence of ODQ by luminescence assay
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