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Inhibition of mutant HTT (unknown origin) at 10 nM relative to control
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity to mutant HTT (unknown origin) mediated HD exon 1-72Q aggregation assessed as dissociation constant
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of mutant HTT (unknown origin) at 100 nM relative to control
Assay data:4 Tested
Inhibition of mutant HTT (unknown origin)
Assay data:1 Active, 3 Tested
Inhibition of HTT (unknown origin)
Assay data:4 Active, 6 Tested
Inhibition of mutant HTT (unknown origin) mediated HD exon 1 protein aggregation
Assay data:2 Tested
Inhibition of HTT (unknown origin) by HTS assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Induction of human HTT degradation in human SH-SY5Y cells assessed as decrease in normal HTT protein levels at 125 nM by Western blot analysis
SummaryPubMed CitationRelated BioAssays by Target
Induction of human HTT degradation in human SH-SY5Y cells assessed as decrease in HTT-transcript levels at 125 nM
Induction of mutant Htt (unknown origin) degradation expressed in human fibroblasts cells assessed as HSP70/CHIP recruitment based proteosome mediated mHtt degradation by western blot analysis
Inhibition of endogenous Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MSD electrochemiluminescence assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MSD electrochemiluminescence assay
Assay data:6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by MSD assay
Alphascreen assay for small molecules abrogating mHTT-CaM Interaction
Assay data:6896 Active, 193105 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense Promoter Activity
Assay data:117 Active, 379 Activity ≤ 1 µM, 48411 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS for Identification of Small Molecule Inhibitors of Huntingtin Promoter Activity
Assay data:449 Active, 429 Activity ≤ 1 µM, 48428 Tested
Confirmatory qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense Promoter Activity
Assay data:39 Active, 17 Activity ≤ 1 µM, 908 Tested
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