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OGG1 Inhibitor Assays from US Patent US11440887: "Substituted 1,2,3,4-tetrahydroquinolines as inhibitors of repair enzyme 8-oxoguanine deoxyribonucleic acid glycosylase activity"
Assay data:6 Active, 3 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Fluorescence-based Assay from Article 10.1021/acschembio.5b00452: "Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1)."
Assay data:15 Active, 7 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Gel-based Cleavage Assay from Article 10.1021/acschembio.5b00452: "Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1)."
Assay data:5 Active, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of human OGG1 catalytic activity assessed as reduction trapping of substrates using AP site containing substrate by measuring concentration of compound needed to reduce borohydride trapping by 50% in presence of sodium cyno-borohydride by gel electrophoresis method
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human OGG1 catalytic activity assessed as reduction trapping of substrates using 8-oxo-Gua substrate by measuring concentration of compound needed to reduce borohydride trapping by 50% in presence of sodium cyno-borohydride by gel electrophoresis method
Assay data:2 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human OGG1 catalytic activity assessed as reduction trapping of substrates at 10 uM using AP site containing substrate in presence of sodium cyno-borohydride by gel electrophoresis method
Assay data:6 Active, 6 Tested
Inhibition of human OGG1 catalytic activity assessed as reduction trapping of substrates at 10 uM using 8-oxo-Gua substrate in presence of sodium cyno-borohydride by gel electrophoresis method
Inhibition of human OGG1 binding to AP site containing substrate assessed as reduction in AP site binding using compound pre-incubated with enzyme for 5 to 10 mins before substrate addition and further incubated for 5 mins by native gel electrophoresis based by gel-shift assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human OGG1 binding to 8-oxo-Gua substrate using compound pre-incubated with enzyme for 5 to 10 mins before substrate addition and further incubated for 5 mins by native gel electrophoresis based by gel-shift assay
Assay data:1 Active, 6 Tested
Inhibition of human OGG1 assessed as protection against NaOH-mediated strand cleavage using AP-containing substrate (Rvb = 100%)
Assay data:7 Tested
Inhibition of human OGG1 assessed as reduction in free Inhibition of human OGG1 assessed as reduction in free FapyGua release using gamma-irradiated calf thymus DNA substrate incubated for 1 hr by GC-MS/MS assay
Assay data:5 Active, 7 Tested
Inhibition of human OGG1 assessed as reduction in free 8-oxo-Gua release using gamma-irradiated calf thymus DNA substrate incubated for 1 hr by GC-MS/MS assay
Inhibition of human OGG1 assessed as reduction in AP lyase activity using AP-containing substrate
Inhibition of human OGG1 at 0.08 to 8 uM incubated for 30 mins using 8-oxo-Gua-containing substrate by PAGE-based cleavage assay
Inhibition of human OGG1 incubated for 30 mins using 8-oxo-Gua-containing substrate by PAGE-based cleavage assay
Inhibition of human OGG1 incubated for 30 mins using 8-oxo-Gua-containing substrate by TAMRA fluorescence-based assay
Inhibition of OGG1 in human HeLa cells assessed as reduction in DNA repair at 200 and 300 uM using 8-oxodG-containing M13mp18 plasmids by plasmid based in-cell repair assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of OGG1 in human A549 cells assessed as reduction in DNA repair at 200 and 300 uM using 8-oxodG-containing M13mp18 plasmids by plasmid based in-cell repair assay
Inhibition of OGG1 (unknown origin) pre-incubated with compound for 10 mins followed by addition of 1,N6 ethenoadenine containing 32P-labeled duplex oligonucleotide substrates at 20 to 40 uM by gel-based excision activity assay
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